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时间:2020-05-12
《电针丰隆穴对高脂血症大鼠血脂及肝脏组织炎症细胞因子的调控作用.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国康复·2015年2月·第3O卷第1期电针丰隆穴对高脂血症大鼠血脂及肝脏组织炎症细胞因子的调控作用乐薇,张红星,王琼,黄国付,周利,覃鹏飞【摘要】目的:探讨电针丰隆穴对高脂血症大鼠肝脏组织炎症细胞因子的调控作用。方法:将3o只健康SD大鼠随机分为正常组、模型组、电针组各10只。电针组给予丰隆穴电针治疗。4周后,检测各组大鼠血脂水平,即总胆固醇(Tc)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)含量,ELISA检测各组大鼠肝脏组织中肿瘤坏死因子一a(TNF-a)、白细胞介素一1p(IL_1p)、干扰素一7(IFN—)蛋白水平变化。结果:治疗
2、后,血脂水平比较,与正常组比较,模型组大鼠TC、TG及LDL-C均显著升高(P<0.01,0.05),HDC显著降低(P<0.05),电针组的TC、LDL-C均显著升高(P<0.01)。与模型组比较,电针组大鼠TC、TG及LDL-C均显著降低(P3、C、LDI,C水平,并能降低肝脏组织中炎症因子TNF-a、IL-I~、IFN-7的蛋白水平变化,对高脂血症具有一定的治疗作用。【关键词】高脂血症;电针;丰隆穴;肿瘤坏死因子一a;白细胞介素一1B;干扰素一7【中图分类号】R49;R589.2IDO1]10.3870/zgkf.2015.01.002Modutoryeffectofelectroacupunctureat”Fengiong”(sT40)onbloodlipidandinflammatoryfactorsinliversofrathy—perlipidemiamodelLPW,ZhangHongxing,Wangong,4、eta1.WuhanHospitalofIntegratedChineseandWesternMedicine,Wuhan430022,China[Abstract]Objective:Tostudythemodutoryeffectofelectroacupunctureatthe’’Fenglong”oninflammatoryfac—torsintheliversofrathyperlipidemiamode1.Methods:ThirtyhealthmaleSDratswereselectedandrandomlydi—videdinto3groups:normalcont5、rolgroup(A),modelcontrolgroup(B),andelectroacupuncturegroup(C).Afterfourweeks,bloodlipidsofratsweredetermined.TheproteinlevelsofTNF-d,IL18andIFN-7intheliversofrathyperlipidemiamodelweredetectedbyELISA.Results:AscomparedwithgroupA,thecontentsofTC,TGandLDI,Cweresignificantlyincreased(P6、0.05)andthecontentofHDL-Cwassignificantlydecreased(P7、-a,IL-I~andIFN-7levelswereincreasedsignificantlyingroupB(P<0.05,andP<0.01).AscomparedwithgroupB,TNF_一d,II,117andIFN-71evelsingroupCweredecreasedsignificantly(P
3、C、LDI,C水平,并能降低肝脏组织中炎症因子TNF-a、IL-I~、IFN-7的蛋白水平变化,对高脂血症具有一定的治疗作用。【关键词】高脂血症;电针;丰隆穴;肿瘤坏死因子一a;白细胞介素一1B;干扰素一7【中图分类号】R49;R589.2IDO1]10.3870/zgkf.2015.01.002Modutoryeffectofelectroacupunctureat”Fengiong”(sT40)onbloodlipidandinflammatoryfactorsinliversofrathy—perlipidemiamodelLPW,ZhangHongxing,Wangong,
4、eta1.WuhanHospitalofIntegratedChineseandWesternMedicine,Wuhan430022,China[Abstract]Objective:Tostudythemodutoryeffectofelectroacupunctureatthe’’Fenglong”oninflammatoryfac—torsintheliversofrathyperlipidemiamode1.Methods:ThirtyhealthmaleSDratswereselectedandrandomlydi—videdinto3groups:normalcont
5、rolgroup(A),modelcontrolgroup(B),andelectroacupuncturegroup(C).Afterfourweeks,bloodlipidsofratsweredetermined.TheproteinlevelsofTNF-d,IL18andIFN-7intheliversofrathyperlipidemiamodelweredetectedbyELISA.Results:AscomparedwithgroupA,thecontentsofTC,TGandLDI,Cweresignificantlyincreased(P6、0.05)andthecontentofHDL-Cwassignificantlydecreased(P7、-a,IL-I~andIFN-7levelswereincreasedsignificantlyingroupB(P<0.05,andP<0.01).AscomparedwithgroupB,TNF_一d,II,117andIFN-71evelsingroupCweredecreasedsignificantly(P
6、0.05)andthecontentofHDL-Cwassignificantlydecreased(P7、-a,IL-I~andIFN-7levelswereincreasedsignificantlyingroupB(P<0.05,andP<0.01).AscomparedwithgroupB,TNF_一d,II,117andIFN-71evelsingroupCweredecreasedsignificantly(P
7、-a,IL-I~andIFN-7levelswereincreasedsignificantlyingroupB(P<0.05,andP<0.01).AscomparedwithgroupB,TNF_一d,II,117andIFN-71evelsingroupCweredecreasedsignificantly(P
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