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时间:2020-05-12
《灯盏花素联合前列地尔治疗脑梗死.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第40卷第4期贵阳医学院学报Vo1.40No.42015年4月JOURNALOFGUIYANGMEDICALCOLLEGE2015.4灯盏花素联合前列地尔治疗脑梗死周大淑(自贡市第一人民医院神经内科,四川自贡643000)[摘要]目的:探讨脑梗死患者采用灯盏花素联合前列地尔的治疗效果及其对神经功能缺损和血液流变学的影响。方法:100例脑梗死(CI)患者随机分成观察组和对照组,对照组给予灯盏花素注射液治疗,治疗组在对照组基础上加用前列地尔治疗,比较两组患者临床疗效及治疗前后的神经功能缺损评分(NIHSS)
2、和血液流变学指标。结果:治疗后,观察组的总有效率为96.00%,显著高于对照组的72.o0%,差异有统计学意义(P<0.05);两组患者治疗后的NIHSS评分均低于治疗前,以观察组更明显(P<0.05);两组治疗后,血液流变学指标水平均显著低于治疗前,以观察组更明显(P<0.05)。结论:在cI患者中采用灯盏花素联合前列地尔治疗,可有效提高临床疗效、减轻患者神经功能缺损程度、改善血流变,具有较高的应用价值。[关键词]灯盏花素;前列地尔;神经功能缺损;脑梗塞;血液流变学[中图分类号]R743.33[文献标
3、识码]A[文章编号]1000.2707(2015)044)401-03ClinicalStudyonEfectofBreviscapineCombinedwithAlprostadilintheTreatmentofCerebralInfarctionZHOUDashu(DepartmentofNeurology,FintPeopleHospitalofZigongCity,Zigong643000,Sichuan,China)[Abstract]Objective:Toinvestigatethecu
4、rativeeffectofbreviscapinecombinedwithalprostadilinpatientswithcerebralinfarctionaswellasitseffectonneurologicaldeficitandhemorheology.Meth-ods:One-hundredpatientsofcerebralinfarctionwererandomlydividedintoobservationgroupandcontrolgroup,thecontrolgroupw
5、eretreatedwithbreviscapineinjection,theobservationgroupwastreatedwithbreviscapineinjectioncombinedwithalprostadil,theNIHSSscore,bloodrheologyindexesbeforeandaftertreatmentandclinicaleffectofbothgroupswerecompared.Results:Totaleffectiverateintheobservatio
6、ngroupwas96%,significantlyhigherthan72%ofthecontrolgroup,thediffer—enceswasstatisticallysignificant(P<0.05);aftertreatment,NIHSSofbothgroupsweresignificantlylowerthanpre—treatment,anddecreaseofobservationgroupwasmoresignificant(P<0.05);thebloodrheologyin
7、dexlevelsweresignificantlylowerthanpre—treatment,anddecreaseofobservationgroupwasmoresignificant(P<0.05).Conclusions:Breviscapinecombinedwithalprostadiltherapyinpatientswithcerebralinfarctioncaneffectivelyimprovetheclinicalcurativeeffect,reducethenervefu
8、nctiondamagedegreeandimprovebloodrheology.[Keywords]breviscapine;alprostadil;nervefunctionimpairment;cerebralinfarction;bloodrheology脑梗死(cerebralinfarction,CI)是一种严重的果,已经是临床探究的重点。本研究通过观察灯盏缺血性脑血管疾病,近年来的发病率、死亡率及致花素联合前列地尔对脑梗死患
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