甲泼尼龙治疗儿童难治性肺炎支原体肺炎的临床分析.doc

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1、甲泼尼龙治疗儿童难治性肺炎支原体肺炎的临床分析　　【摘要】目的探�甲泼尼龙在儿童难治性肺炎支原体肺炎中的临床应用和疗效。方法70例RMPP患儿，随机分为对照组和观察组，各35例。两组均采用红霉素抗感染治疗，体温稳定48h后改阿奇霉素口服序贯治疗，观察组在抗感染的基础上同时使用甲泼尼龙2mg/静脉滴注治疗。观察两组患儿体温恢复正常时间、咳嗽缓解时间和肺部��音消失时间，对比治疗前后两组患儿中性粒细胞比值、C反应蛋白和血清铁蛋白改善情况。结果观察组患儿体温恢复正常时间、咳嗽消失时间和肺部��音消失时间分别为、、d，均短于对照组的、、d，差异具有统计学意义。治疗后，两组患儿中性粒细胞比值

2、、C反应蛋白、血清铁蛋白等炎症相关指标均较治疗前改善，且观察组患儿改善程度优于对照组，差异具有统计学意义。结论对于RMPP患儿，在使用大环内酯类抗生素的基础上同时给予甲泼尼龙，能显著缩短症状和体征持续时间，改善炎性指标，加快患儿恢复。　　【关键词】难治性肺炎支原体肺炎；儿童；甲泼尼龙　　DOI：10.14163/j.cnki.11-5547/r.2017.15.003　　ClinicalanalysisofmethylprednisoloneinthetreatmentofchildrenrefractorymycoplasmapneumoniaepneumoniaYUJie-mi

3、ng，WANGXing，WUChun-yuan，etal.DepartmentofPediatrics，ShenzhenAffiliatedMaternalandChildHealthCareHospitalofSouthernMedicalUniversity，Shenzhen518028，China　　【Abstract】ObjectiveToinvestigateclinicalapplicationandcurativeeffectbymethylprednisoloneinthetreatmentofchildrenrefractorymycoplasmapneumoni

4、aepneumonia.MethodsAtotalof70RMPPchildrenpatientswererandomlydividedintocontrolgroupandobservationgroup，with35casesineachgroup.Bothgroupsreceivederythromycinforanti-infectiontreatment，followedbyoraladministrationofazithromycinassequentialtherapyafter48hwithstablebodytemperature.Theobservationg

5、roupreceivedadditionalmethylprednisoloneby2mg/throughintravenousdripfortreatment.Observationwasmadeonbodytemperaturerecoverytime，coughremissiontimeandlungraledisappearancetimeinthetwogroups.Comparisonwasmadeonimprovementsofneutrophilratio，C-reactiveproteinandserumferritinbetweenthetwogroupsbef

6、oreandaftertreatment.ResultsTheobservationgrouphadbodytemperaturerecoverytime，coughremissiontimeandlungraledisappearancetimerespectivelyas，andd，whichwereallshorterthan，anddinthecontrolgroup，andtheirdifferencehadstatisticalsignificance.Aftertreatment，bothgroupshadimprovementsofneutrophilratio，C

7、-reactiveproteinandserumferritin，andtheobservationgrouphadbetterimprovementdegreethanthecontrolgroup，andthedifferencehadstatisticalsignificance.ConclusionImplementofmethylprednisoloneinadditiontomacrolidesantibioticsforRMPPchildrencanre