川芎嗪注射液联合米力农治疗COPD并发慢性肺心病急性加重期的临床研究.pdf

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1、·50·2015年4月第35卷第4期ClinicalMcdicine，Apt"．2015，Vo1．35，No．4川芎嗪注射液联合米力农治疗COPD并发慢性肺心病急性加重期的I临床研究张遂甫陈晓平尚艳张腾(河南省舞阳县人民医院呼吸内科，舞阳462400)【摘要】目的研究川芎嗪注射液联合米力农治疗慢性阻塞性肺疾病(COPD)并发慢性肺心病急性加重期的临床疗效。方法采用随机、平行对照的研究方法，将98例COPD并发慢性肺心病急性加重期患者随机分成两组。对照组(49例)给予常规治疗，观察组(49例)在常规治疗的基础上加用川芎嗪注射液和米力衣，

2、疗程10d。观察各组症状、体征、心功能、肺动脉压、脑钠肽和D一二聚体水平的变化情况。结果观察组总有效率89．8％，明显优于对照组的67．3％，两组差异比较有统计学意义(P<0．05)；观察组肺动脉压、脑钠肽和D一二聚体水平降低程度均明显大于对照组，两组比较差异有统计学意义(P均<0．05)。结论川芎嗪注射液联合米力农治疗COPD并发慢性肺心病急性加重期有更好的疗效。【关键词】川芎嗪注射液；米力农；慢性肺心病；肺动脉高压Clinicalresearchofligustrazineinjectioncombinedwithmilrinon

3、einthetreatmentofchronicobstructivepulmonarydiseasecomplicatedwithactueexacerbationofchroniccorpulmonaleZHANGSui-fu，CHENXiao-ping，SHANGYah，ZHANG．DepartmentofRespiratoryMedicine，WuyangPeople’5Hospital，Wuyang462400，China【Abstract】0bjectiveTostudytheclinicalefficacyofligus

4、trazineinjectioncombinedwithmilrinoneonchronicobstructivepulmonarydisease(COPD)complicatedwithacuteexacerbationexacerbationofchroniccotpulmonale．MethodsNinetypa—tientswithCOPDcombinedwithacuteexacerbationofchroniccorpulmonalewereallgivenconventionaltreatmentandthenwerer

5、andomlydividedintotwogroups：49patientsofcontrolgroupweretreatedwithroutinetherapy，while49patientsofobservationgroupweregivenligustrazineinjectionandmilrinoneonbasisofroutinetherapy．Thecourseoftreatmentwas7days．Symptomsandsignsofheanfailure，heartfunction，pulmonaryarteryp

6、ressure，brainnatriuretiepeptide(BNP)，andD—Dimerwereobserved．ResultsThetotalefectiverateswere89．8％and67．3％respectivelyintheobservationgroupandinthecontrolgrouprP<0．05)；anddownscaleofpulmonaryarterypressure(PAP)weredistinctlygreaterthanthecontrolgroup。BNPandD-Dimerintheob

7、servationgroupdecreasedobviously，thedifferenceswerestatisticallysignificantcomparedwithcontrolgroup(P<0．05)．ConclusionLigustrazineinjectioncombinedwithmilrnonecanbeeffectiveonCOPDpatientscomplicatedwithacuteexacerbationofchroniccorpulmonary．【Keywords】Ligustrazineinjecti

8、on；Milrinone；Chroniccorpulmonale；Pulmonaryarteryhighpressure慢性肺心病是一种严重危害人类健康的常见病和1对象与方法多发病，其并发症多，病死率高。慢性阻塞性肺疾病