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时间:2020-05-09
《鳖甲煎丸联合恩替卡韦对乙肝肝纤维化的疗效观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·6·中国现代药物应用2015年4月第9卷第7期ChinJModDrugAppl,Apr2015,V01.9,N0.7鳖甲煎丸联合恩替卡韦对乙肝肝纤维化的疗效观察梁贤栋刘关静李园园【摘要】目的观察鳖甲煎丸联合恩替卡韦治疗乙型肝炎(简称:乙肝)肝纤维化的疗效。方法乙型肝炎肝纤维化患者100例,随机分为治疗组和对照组,各50例。治疗组患者给予恩替卡韦分散片口服,同时服用鳖甲煎丸;对照组患者只给予恩替卡韦分散片口服;两组患者前期均给予保肝降酶药物应用,均以48周为1个治疗周期。观察患者一般感受,如乏力、纳差、上腹部不适等,治疗前及治疗中第4、12、24、36、48
2、周检测乙肝五项、HBV—DNA及肝功能[总胆红素(TB1L)、谷丙转氨酶(ALT)、白蛋白(ALB)],分别于治疗前和治疗48周后检测血清肝纤维化指标[层粘连蛋白(LN)、透明质酸fHA)、四型胶原(Ⅳ一c),Ⅲ型前胶原(PcⅢ)o用肝纤维化扫描仪(FibroScan)检测治疗前后肝脏硬度值,统计两组患者的最终疗效。结果治疗48周后两组患者一般症状均明显改善;与治疗前比较两组患者肝功指标均明显改善,HBV—DNA大部分阴转。差异均具有统计学意义(P0.05)。两组患者肝纤维化程度较治疗前均改善(P<0.05),治疗组优
3、于对照组(P4、CU.BranchInstituteofShangqiutheFirstPeople’Hospital,Shangqiu476100,China【Abstract】objectiveToobservethecurativeeffectofCara'paxTrionycisdecoctpillcombinedwithenteeavirinthetreatmentofhepatitisBfibrosis.MethodsAtotalof100patientswithhepatitisBfibrosiswererandomlydividedintotreatment5、groupandcontrolgroup,with50casesineachgroup,ThetreatmentgroupreceivedoraladministrationofentecavirdispersibletabletandCarapaxTrionycisdecoctpil1.Thecontrolgroupwasgivenentecavirdispersibletabletalone.Bothgroupsreceiveddrugsforliverprotectingandtransaminaseloweringeffect,andtheirtre6、atmentlastedfor48weeksas1course.Observationwasmadeonpatients’feelings,suchaslackinginstrength,anorexia,andepigastricdiscomfort.DetectionsweremadeonfiveitemsofhepatitisB,HBV-DNA,andliverfunction[totatbilirubin(TBIL),glutamic-pyruvictransaminase(AI』T),albumin(ALB)】in4,12,24,36,and48w7、eeksoftreatment.Serumindicatorsofhepaticfibrosis[1aminin(LN),hyaluronicacid(HA),IV—collagen(IV—C),procollagenllI(pcllI)】weredetectedbeforetreatmentandafter48-weektreatment.FibroScanwasappliedindetectionofliverstiffnessvaluesbeforeandaftertreatment,andthefinalcurativeeffectwasevalua8、ted.ResultsAfter48weeksoft
4、CU.BranchInstituteofShangqiutheFirstPeople’Hospital,Shangqiu476100,China【Abstract】objectiveToobservethecurativeeffectofCara'paxTrionycisdecoctpillcombinedwithenteeavirinthetreatmentofhepatitisBfibrosis.MethodsAtotalof100patientswithhepatitisBfibrosiswererandomlydividedintotreatment
5、groupandcontrolgroup,with50casesineachgroup,ThetreatmentgroupreceivedoraladministrationofentecavirdispersibletabletandCarapaxTrionycisdecoctpil1.Thecontrolgroupwasgivenentecavirdispersibletabletalone.Bothgroupsreceiveddrugsforliverprotectingandtransaminaseloweringeffect,andtheirtre
6、atmentlastedfor48weeksas1course.Observationwasmadeonpatients’feelings,suchaslackinginstrength,anorexia,andepigastricdiscomfort.DetectionsweremadeonfiveitemsofhepatitisB,HBV-DNA,andliverfunction[totatbilirubin(TBIL),glutamic-pyruvictransaminase(AI』T),albumin(ALB)】in4,12,24,36,and48w
7、eeksoftreatment.Serumindicatorsofhepaticfibrosis[1aminin(LN),hyaluronicacid(HA),IV—collagen(IV—C),procollagenllI(pcllI)】weredetectedbeforetreatmentandafter48-weektreatment.FibroScanwasappliedindetectionofliverstiffnessvaluesbeforeandaftertreatment,andthefinalcurativeeffectwasevalua
8、ted.ResultsAfter48weeksoft
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