阿托伐他汀对急性缺血性脑卒中患者血清hs-CRP TNF-α的影响.pdf

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1、中国实用神经疾病糸志2015生箜鲞箜塑堡!!!!!里!!!!!堕!!!』：!!：．!：兰’33‘阿托伐他汀对急性缺血性脑卒中患者血清hs—CRPTNF-a的影响江玲重庆市璧山县人民医院内四科壁山402760【摘要】目的探讨急性缺血性脑卒中(AIS)患者血清hs—CRP、TNF_a的变化及阿托伐他汀的干预作用。方法选择76例AIS患者为研究对象，根据临床神经功能缺损程度评分标准分为轻型组、中型组及重型组，3O例健康体检者纳入对照组，比较各组患者血清hs—CRP、TNF-a水平；随机将76例患者分为2组，常

2、规组予抗血小板等常规治疗，他汀组联合阿托伐他汀治疗，比较治疗前后2组血清hs—CRP、TNF_水平的变化。结果轻型组、中型组、重型组AIS患者血清hs—CRP及TNF_a水平均明显高于对照组(P

3、程度，而阿托伐他汀可有效抑制AIS患者的炎症因子水平，进而改善患者预后。【关键词】急性缺血性脑卒中；阿托伐他汀；炎症因子；神经功能缺损【中图分类号】R743．3【文献标识码】A【文章编号】1673—5110(2015)02—0033—02Effectsofatorvastatinontheserumhs—CRPandTNF-alevelsofpatientswithacuteisehemicstrokeJianglingeFourthDepartmentofInternalmedicine，thePeo

4、ple'sHospitalofBishan，Bishan402760，China[Abstract]ObjectiveToinvestigatetheeffectsofatorvastatinontheserumhs-CRPandTNFalevelsofpatientswitha—cuteischemicstroke(AIS)．Methods76patientswithAISweredividedintolightgroup．mediumgroupandheavygroupac—cordingtocli

5、nicalneurologicalimpairmentscorestandards．30healthyvolunteerswereconsideredascontrolgroup．76patientswithAISweredividedintoconventionalgroup(treatedwithconventionaltherapy)andatorvastatingroup(treatedwithatorv-astatin)．Theserumhs-CRP，TNF-alevelsoftwogroup

6、swerecompared．ResultsTheserumhs—CRPandTNF-dlevelsinpa—tientswithAISweresignificantlyhigherthantheseincontrolgroup．Theheaviertheneurologicalfunctionimpairmentofpa—tientswithAISwas，thehighertheserumhs—CRPandTNF-a1evelswere．Theserumhs—CRPandTNF-a1evelsofato

7、rvastatingroupwerelowerthantheseofcontrolgroup．ConclusionTheserumlevelsofCRPandTNF-aofpatientswithAIScanreflectpatients’illnessdegree，andatorvastatincaneffectivelyinhibitinflammatorycytokinelevelstoimprovethepatients’progno—SlS．[Keywords]Acuteischemicstr

8、oke；Atorvastatin；Inflammatorycytokines；Neurologicaldeficit急性缺血性脑卒中(acuteischemicstroke，AIS)是临床服，1次／d，疗程14d。上常见神经内科疾病之一，占全部脑卒中患者的5O以上，1．3观察指标对照组于入组次日、AIS患者于治疗前后具有较高的致死及致残率，对患者的健康及生活质量造成严抽取空腹静脉血，采用增强透射免疫分析法测定血清hs—重威胁_1]。动脉粥样