基质金属蛋白酶抑制剂-1与慢性乙型肝炎肝纤维化发生发展的相关性分析-论文.pdf

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1、辽孝压学陀亏揠2013DecJLiaoningMMeeddiiccaallUniversity⋯⋯u．‘34(6)g基质金属蛋白酶抑制剂一1与慢性乙型肝炎肝纤维化发生发展的相关性分析沈慧杰，褚瑞海(1．潍坊医学院；2．潍坊市人民医院感染科，山东潍坊261041)摘要：目的探讨慢性乙型肝炎患者血清基质金属蛋白酶抑制剂一1(TIMP一1)水平与肝纤维化发生发展的相关性及其意义。方法随机选取30例健康体检者(对照组)、35例慢性乙型肝炎患者(CHB组)、33例乙肝肝硬化惠者(LC组)作为研究组，采用酶联免疫法(ELISA)分别测定各组血清TIMP一1及肝纤维化四项(透明质酸(H

2、A)、Ⅲ型前胶原(PC—llI)、Ⅳ型胶原(Ⅳ一c)、层粘连蛋白(LN))水平。结果(1)CHB组、Lc组血清TIMP一1水平分别为(139．7±13．1)L、(280．6±l8．4)L均高于对照组(85．6±11．2)g／L(P<0．05)；(2)血清TIMP一1水平从CHB组到Lc组呈递增性，差异有统计学意义(P<0．05)；(3)血清TIMP一1与HA、PC—HI、1V—C、LN呈显著正相关(P<0．05)。结论TIMP—l与乙型肝炎肝纤维化的发生发展密切相关，联合肝纤维化四项检测对乙型肝炎肝纤维化的诊断有一定价值。关键词：基质金属蛋白酶抑制剂一1；细胞外基质；慢性

3、乙型肝炎；肝纤维化中图分类号：R575．1文献标志码：A文章编号：1674—0424(2013)06—0014—03AnalysisoftheCorrelationbetweenMatrixMetalloproteinaseInhibitor--1andtheOccurrenceandDevelopmentofLiverFibrosisinChronicHepatitisBSHENHuijie，CHURuihai(1．WeifangMedicalUniversity；2．DepartmentofInfectiousDiseases，People’sHospitalofWe

4、ifang，Weifang261041China)Abstract：ObjectiveToin'~estigatethecorelationbetweenMatrixMetalloproteinaseInhibitor一1andtheOccur—renceandDevelopmentofLiverFibrosisinChronicHepatitisB，anditssignificanceaswel1．Methods30casesofthephysicallyhealthywerecollectedasthecontrolgroup，35casesofchronichepa

5、titisBwerecollectedastheCHBgroup，33casesofhepatitisBlivercirrhosis(LCgroup)werecollectedastheexperimentalgroup，andtheserumTIMP—llevelsandthefourindexesofliverfibrosis(HA，PCm，IV—c，LN)weredetectedbyenzyme—linkedimmunoassay(ELISA)ineverycaseabove．Results(1)TheserumlevelsofTIMP一1inCHBgroupand

6、LCgroupare(139．7±13．1)Land(280．6±18．4)Lrespectively，whichwerehigherthanthoseincontrolgroup(85．6±11．2)L(P<0．05)．(2)TheseiTlmlevelsofTIMP—1wereincreasingfromCHBgrouptoLCgroup，thedifferencewasstatisticallysignificant(P<0．05)．(3)TherewassignificantlypositivecorrelationbetweentheserumTIMP一1lev

7、elsandHA，PCⅢ，IV—CandLN(P<0．05)．ConclusionTIMP一1iscloselyrelatedtotheoccurrenceanddevelopmentofhepatitisBliverfibro—sis，andthejointdetectionofthefourindexesofliverfibrosisisacertaindegreevaluabletothediagnosisofhepatitisBliv—erfibrosis．Keywords：matrixmetalloproteinas