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时间:2020-05-08
《不同评分系统对乙肝相关慢加急性肝衰竭患者短期预后评估的比较-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、实用医学杂志2014年第30卷第4期57l不同评分系统对乙肝相关慢加急性肝衰竭患者短期预后评估的比较刘磊王凤梅阚志超李岩肖时湘刘华李莹摘要目的:通过对几种不同评分系统比较,找出更适合乙肝相关慢加急性肝衰竭患者短期预后评估的方法方法:将142例乙肝相关慢加急性肝衰竭患者根据其3个月后的存活及死亡情况.分为存活组(n:72)及病死组(n=70),分别计算CTP、MELD、ANN、SOFA、SMSVH、LRM等评分,行ROC曲线分析,计算曲线下面积.并进行比较。结果:ROC曲线下面积从大到小分别为ANN、SOFA、LRM、MELD、CTP、SMSVH,相应数值分别
2、为0.92、0.89、O.89、0.87、0.78和0.69。ANN、SOFA、LRM、MELD的AUC之间比较差异无统计学意义(P>0.05),ANN、SOFA、LRM、MELD的AUC值>CTP、SMSVH,差异有统计学意义(P均<0.05),CTP的AUC值>SMSVH,差异有统计学意义(P<0.05)。结论:ANN、sOFA、LRM、MELD较好;CTP稍差;SMSVH最差。不适用于乙肝相关慢加急性肝衰竭患者短期预后判断。ANN可能为最佳评分系统,但仍需大样本、多中心、动态的临床观察来证实。关键词评分系统;乙型肝炎;慢加急性肝衰竭;预后;受试者工作特
3、征曲线;曲线下面积Comparisonofdifferentscoringsystemsevaluatingshort-termprognosisofpatientswithhepatitisBassociatedacutehepaticfailureLIULei,GNFeng-mei,KANZhi—chao,L1Yah,X1A0Shi—xiang,£ⅢHua,LIring.DepartmentofHepatobiliaryDisease,TianjinrdCentralHospital,TianjinInstituteofHepatobiliaryDise
4、ase,TianjinKeyLaboratoryofArtifcialCell,Tianjin300170,China【Abstract】ObjectiveToassessmentshort—termprognosisinpatientswithacuteonchronicliverfailure,severalscoringsystemswerecompared.MethodsTwohundredandsixteenpatientswithacuteonchronicliverfailureweredividedintosurvivalgroupandde
5、athgroupaccordingtotheresultsof90daysafteradmission.CTP,MELD.APACHEII.SOFAandSMSVHscorewerecalculated.AfterROCcurveswereperformed,theareasunderthecurvesofthesescoringsystemswerecompared.ResultsTheareasundertheROCCurvesofMELD.APACHEⅡ,SOFA,CTPandSMSVHwere0.88,0.76,0.89,0.79and0.69,re
6、spectively.TheareasunderthecurvesofS0FAandMELDwerelargerthantheAPACHEI1.CTPandSMSVH(P<0.05).TherewasnodifferencebetweentheSOFAandMELD(P>0.05).,I’heareaundertIlecurveofCTPwaslargerthantheAPACHEII.buttherewasnostatisticallysignificantdifference(P>0.05).TheareaunderthecurveofSMSVHwere
7、lessthan0.7.ConclusionsTheSOFA.MELD.CTPandAPACHEⅡcanpredicttheshort.termprognosisofacuteonchronicliverfailure.TheSOFAandMELDarethebestscoringsystems.CTP.APACHElIarebetterthanSMSVH.SMSVHfailtopredicttheprognosisofacuteonchronicliverfailure.【Keywords】Scoringsystem;Acuteonchronicliver
8、failure;Prognosis;receiver
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