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时间:2020-05-07
《Hp感染与肝硬化患者血氨水平及肝功能分级的关系-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、2013年第17卷第19期实用临床医药杂志JoumalofClinicalMedicineinPractice·l17·Hp感染与肝硬化患者血氨水平及肝功能分级的关系胡来明(湖北医药学院附属襄阳医院老年病科,湖北襄阳,441000)摘要:目的探讨幽门螺杆菌(Hp)感染与肝硬化患者血氨水平及肝功能分级的关系。方法选择1】8例肝硬化患者为研究对象,其中}感染阳性者78例,Hp阴性者40例。记录2组肝性脑病发生率、检测血氨水平,同时给予}Ip阳性者Hp根除治疗,比较治疗前后血氨水平的改变。结果Hp阳性者肝
2、性脑病发生率为60.3%,显著高于Hp阴性者的32.5%(P<0.05);Hp阳性者血氨水平显著高于Hp阴性者(P<0.05);在Child—PughA、B及c级患者中,H
3、p阳性者血氨水平逐渐升高(P<0.05),而在}阴性者则未见显著差异(P>0.05);Hp阳性者行Hp根除治疗后,血氨水平显著下降(P<0.05)。结论肝硬化Hp感染者血氨水平显著升高,肝性脑病发生率高。Hp根除治疗可显著降低血氨水平,有利于肝性脑病的防治。关键词:肝硬化;幽门螺杆菌;血氨;肝功能分级;肝性脑病中图分类号:R65
4、7.3文献标志码:A文章编号:1672—2353(2013)19—117—03D0I:10.7619/jcmp.201319043RelationshipofHpwithbloodammoniaandliverfunctiongradeinpatientswithlivercirrhosisHULaiming(XiangyangHospitalAffiliatedtoHubeiMedicalCollege,Xiangyang,Hubei,441000)ABSTRACT:ObjectiveToexpl
5、oretherelationshipofHpwithbloodammoniaandliverfunc—tiongrade.MethodsAtotalof118patientswithlivercirrhosiswereselectedasresearchsubjects,including78Hppositivecasesand40Hpnegativecases.Theoccurrencesofhepaticencephalopathywererecordedandtheblodammonialev
6、elsweredetected.TheHppositivepatientsreceivedHperadicationtherapy.Thechangesofbloodammonialevelwerecomparedbeforeandaftertreatment.ResultsTheoccurrenceofhepaticencephalopathyinHppositivepatientswasmuchhigherthanthatinHpnegativepatients(60.3%VS32.5%,P<0
7、.05).WithHpnegativepatients,blodain—monialevelinHppositivepatientsgreatlyincreased(P<0.05).Inchild—pughA,BandCgradepatients,bloodammonialevelgraduallyincreasedinHppositivepatients(P<0.05);TherewerenosignificantdifferencesofblodammoniaamongChild—PughA,B
8、andCgradepatientsinHpnegativegroup(P>0.05).Aftertreatment,blodammonialevelgreatlydecreasedinHppositivepatients(P<0.05).ConclusionTheblodammonialevelandtheoccurrenceofhepaticen—cephalopathygreatlyincreaseinHppositivepatients.Hperadicationtherapycansigni
9、ficantlyde—creasetheblodammonialevelandbebenefitforpreventionofhepaticencephalopathy.KEYWORDS:livercirrhosis;helicobacterpylori;blodammonia;hepaticencephal0pathy肝硬化是消化科最为常见的慢性肝病之一,菌(Hp)与消化性溃疡及慢性胃炎的发病关系密是由不同病因引起的长期弥漫性肝损害。肝硬化切[,目前研究发现其与肝硬
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