慢性肝衰竭患者真菌感染的危险因素分析-论文.pdf

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1、·4582·中华医院感染学杂志2013年第23卷第18期ChinJNosocomiolVo1．23No．182013论著慢性肝衰竭患者真菌感染的危险因素分析罗燕，熊晏，林炳亮(1．贵州省人民医院感染科，贵州贵阳550002；2．广州中山大学附属第三医院传染科，广东广州510630)摘要：目的探讨慢性肝衰竭患者真菌感染的相关危险因素，为临床防治提供依据。方法选取广州中山大学附属第三医院2010年1月一2012年1月收治的6o例慢性肝衰竭合并真菌感染患者作为研究对象，设为感染组，将同期未发生真菌感染60例患者设为对照组，对两组患者感染相关因素进行对比分析

2、。结果感染组病死率10．0，明显高于对照组的5．0，差异有统计学意义(P

3、；危险因素中图分类号：R379文献标识码：A文章编号：1005—4529(2013)18-4582—03RiskfactorsforfungalinfectionsinpatientswithchronicliverfailureLUOYan。XIONGYan。LINBing—liang(*GuizhouPeopleSHospital，Guiyang，Guizhou5500022，China)Abstract：OBa『ECTIVEToanalyzetherelatedriskfactorsforfungalinfectionsinpatientswi

4、thchronicliverfailureSOastoguidetheclinicaltreatment．METHODSAtotalof60casesofchronicliverfailurepatientscomplicatedwithfungalinfections，whoweretreatedinthehospitalfromJan2010tOJan2010，wereenrolledinthestudyandassignedastheinfectiongroup，and60casesofpatientswithoutinfectionswere

5、setasthecontrolgroup，thentherelatedfactorsfortheinfectionswereanalyzedandcomparedbetweenthetwogroups．RESULTSThemortalityoftheinfectiongroupwas10．0，significantlyhigherthan5．0ofthecontrolgroup，thedifferencewassignificant(P<0．05)．Theincidenceofbacterialinfectionswas78．33％intheinfe

6、ctiongroup，18．33inthecontrolgroup；theutilizationrateofantibioticswas93．33intheinfectiongroup，46．67inthecontrolgroup；therewere55casesofpatientswhounderwenttheinvasiveoperationintheinfectiongroupand18casesinthecontrolgroup，thedifferencebetweenthetwogroupswassignificant(P<0．05)．Th

7、elogisticregressionanalysisshowedthatthespeciesofpathogenscausinginfectionduringhospitalstay，totalbilirubinindexofliverfunction，lengthofhospitalstay，cumulativetimeofuseofantibiotics，invasiveoperation，andtypesofantibioticsusedweretheinde—pendentriskfactorsforfungalinfectionsinth

8、epatientswithchronicliverfailure．CONCLUSIONItisnecessa