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时间:2020-05-07
《不同粒径纳米和常规微米SiO2对大鼠肺、肝、心、睾丸组织的氧化损伤作用-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、虫国疗养医学2014年第23卷第2期ChinJConvalescentMed,Feb.2014,V01.23.N0.2·97··论著·文章编号:1005~619X(2014)02—0097—03不同粒径纳米和常规微米SiO2对大鼠肺、肝、心、睾丸组织的氧化损伤作用高艳荣余艳琴贾玉巧高冰白钢郝金奇(包头医学院公共卫生学院,014060)【摘要】目的探讨不同粒径纳米和常规微米sio对大鼠肺、肝、心、睾丸组织的氧化损伤作用。方法采用气管直接滴注法给大鼠染毒,滴注后48h处死大鼠,测定肺、肝、心、睾丸组织超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH—Px)活性及脂质过氧化作用(LPO)
2、水平。结果①在675mg/kg剂量下,20F/ITISiO、60rimSiO均可引起肺、肝、睾丸组织SOD活性显著降低(P0.05)。②在67.5mg/kg剂量下,20nlTlSiO2、60nmSiO及微米SiO2均可引起肺、肝脏GSH—Px活性显著降低(P3、PO水平显著升高(P<0.05),M.20nmSiO2还引起心肌组织LPO水平显著升高(P4、meterandconventionalmi.eronsonratlung,liver,heart,andtesticulartissue.MethodsRatsweregivendirecttrachealinstillationforcontaminationandwereputtodeathafter48h,thentheactivitiesofSOD,GSH—Px,thelevelsofLPOinlungs,livers,hearts,andtesticulartissuesofratsweremeasured.Results0)In67.5mg/kgdose,20nnlSiO2a5、nd60nmSiO2causedsignificantdecreaseofSODactivitiesinliver,lung,andtesticulartis—sues(P<0.05),butmicro—SiO2causedonlydecreaseofSODactivitiesinlungs(P<0.05).SODactivitiesinheartsshowednosignificantchanges(P>0.05).②In67.5mg,kgdose,20nnlSiO2,60nmSiO2,andmicroSiO2causeddecreaseofGSH-Pxactivitiesinliver6、sandlungs(P<0.05),and20nn-iSi02alsocauseddecreaseofGSH-Pxacfividesincardiacmuscletissues(P<0.05),butmicroSi02causedonlyde—creaseofGSH—Pxactivitiesinlungs(P<0.05).⑧20nmSi02,60nnlSiO2causedclearincreaseofthelevelsofLPOinlungs,livers,andtes—ticulartissues(P<0.05),and20nmSiO2alsocausedclearincreaseoft7、helevelsofLPOincardiacmuscletissues(P<0.05),butmicroSiO:causedonlyclearincreaseofthelevelsofLPOinlungs(P<0.05).ConclusionMicroSiO2onlycausesoxidativedamagetolungtis-sues,but20nmSiO2and60nmSi02cancauseoxidativedam
3、PO水平显著升高(P<0.05),M.20nmSiO2还引起心肌组织LPO水平显著升高(P4、meterandconventionalmi.eronsonratlung,liver,heart,andtesticulartissue.MethodsRatsweregivendirecttrachealinstillationforcontaminationandwereputtodeathafter48h,thentheactivitiesofSOD,GSH—Px,thelevelsofLPOinlungs,livers,hearts,andtesticulartissuesofratsweremeasured.Results0)In67.5mg/kgdose,20nnlSiO2a5、nd60nmSiO2causedsignificantdecreaseofSODactivitiesinliver,lung,andtesticulartis—sues(P<0.05),butmicro—SiO2causedonlydecreaseofSODactivitiesinlungs(P<0.05).SODactivitiesinheartsshowednosignificantchanges(P>0.05).②In67.5mg,kgdose,20nnlSiO2,60nmSiO2,andmicroSiO2causeddecreaseofGSH-Pxactivitiesinliver6、sandlungs(P<0.05),and20nn-iSi02alsocauseddecreaseofGSH-Pxacfividesincardiacmuscletissues(P<0.05),butmicroSi02causedonlyde—creaseofGSH—Pxactivitiesinlungs(P<0.05).⑧20nmSi02,60nnlSiO2causedclearincreaseofthelevelsofLPOinlungs,livers,andtes—ticulartissues(P<0.05),and20nmSiO2alsocausedclearincreaseoft7、helevelsofLPOincardiacmuscletissues(P<0.05),butmicroSiO:causedonlyclearincreaseofthelevelsofLPOinlungs(P<0.05).ConclusionMicroSiO2onlycausesoxidativedamagetolungtis-sues,but20nmSiO2and60nmSi02cancauseoxidativedam
4、meterandconventionalmi.eronsonratlung,liver,heart,andtesticulartissue.MethodsRatsweregivendirecttrachealinstillationforcontaminationandwereputtodeathafter48h,thentheactivitiesofSOD,GSH—Px,thelevelsofLPOinlungs,livers,hearts,andtesticulartissuesofratsweremeasured.Results0)In67.5mg/kgdose,20nnlSiO2a
5、nd60nmSiO2causedsignificantdecreaseofSODactivitiesinliver,lung,andtesticulartis—sues(P<0.05),butmicro—SiO2causedonlydecreaseofSODactivitiesinlungs(P<0.05).SODactivitiesinheartsshowednosignificantchanges(P>0.05).②In67.5mg,kgdose,20nnlSiO2,60nmSiO2,andmicroSiO2causeddecreaseofGSH-Pxactivitiesinliver
6、sandlungs(P<0.05),and20nn-iSi02alsocauseddecreaseofGSH-Pxacfividesincardiacmuscletissues(P<0.05),butmicroSi02causedonlyde—creaseofGSH—Pxactivitiesinlungs(P<0.05).⑧20nmSi02,60nnlSiO2causedclearincreaseofthelevelsofLPOinlungs,livers,andtes—ticulartissues(P<0.05),and20nmSiO2alsocausedclearincreaseoft
7、helevelsofLPOincardiacmuscletissues(P<0.05),butmicroSiO:causedonlyclearincreaseofthelevelsofLPOinlungs(P<0.05).ConclusionMicroSiO2onlycausesoxidativedamagetolungtis-sues,but20nmSiO2and60nmSi02cancauseoxidativedam
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