TACE联合^125I放射性粒子植入治疗原发性肝癌临床疗效观察-论文.pdf

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1、·40·中国实用医刊20l4年3月第41卷第5期ChineseJournalofPracticalMedicineMar，2014，Vo1．41．No．5TACE联合5I放射性粒子植入治疗原发性肝癌临床疗效观察易爱芬【摘要】目的探讨肝动脉化疗栓塞(TACE)联合I放射性粒子植入治疗原发性肝癌(HCC)的疗效。方法采用抽样调查的方法，选取38例患者接受TACE治疗后2周行CT扫描，制定I放射性粒子植入计划。植入术后进行cT扫描和甲胎蛋白检查，并定期随访。结果38例患者在术中、术后均未发生并发症，完全缓解7例，部分缓解22例，病变稳

2、定4例，病变进展5例，总有效率为86．84％。血液甲胎蛋白(AFP)术后2周下降至(894±98)ng／ml，术后1个月下降至(225±19)ng／ml，相对于术前的(13284-194)g／L明显下降(P<0．05)。术后2周38例患者均未发现明显的肝功能异常变化。结论TACE联合I粒子植入术是HCC治疗的一种安全有效的方法。【关键词】原发性肝癌；肝动脉化疗栓塞；I粒子；介入治疗ClinicaleficacyobservationofTACEcombinedwithIradioactiveparticlesimplantati

3、oflinthetreatmentofhepatocellularcarcinoma}1／Ai-fen．TheFifthPeople’SHospitalofAnyang，Anyang455000．China【Abstract】0bjectiveToinvestigatetheclinicaleffectoftranscatheterarterialchemoembolization(TACE)combinedwithIradioactiveparticlesimplantationonthetreatmentofhepatoce

4、uularcarci．noma(HCC)．MethodsThemethodofsamplinginvestigationwasapplied，and38patientswereselect．edtohaveCTscanat2weeksafterTACE．meanwhiletheplanofIradioactiveparticlesimplantationwasmade．Aftertheoperation，scanCT，AFPdetectionandregularfollow．upwasmade．ResllltsA．mongthe

5、38patients，therewerenocomplicationsduringorafteroperationsand7caseshadcompletere—mission，postoperativepartialremission22caseshad，4caseswerestable，and5caseshadprogressionofdisease，thetotaleficiencywas86．84％．Attwoweeksafteroperation．theAFPlevelwasf894±98)ng／mlandatonem

6、onthafteroperation，thatwas(2254-19)ng／ml，comparedwiththatbeforeopera—tion[(13284-194)g／L]，thereweresignificantdifferences．During2weeksafteroperation，abnormalliverfunctionchangeswerenotfoundamongthe38patients．ConclusionsTACEcombinedwithIra．dioactiveparticlesimplantati

7、onisasafeandeffectivemethodforthetreatmentofHCC．【Keywords】Hepatocellularcarcinoma；Transcatheterarterialchemoembolization；Iradioac．tireparticles；Interventionaltherapy原发性肝癌(hepatocellularcarcinoma，HCC)是最多次后，肝癌的血供随着侧支循环建立、门静脉血供及常见的消化系统恶性肿瘤之一，严重威胁人民群众的肝动静脉分流等情况的发生而复杂化，进而

8、影响了肝生命及健康，是我国最常见的恶性肿瘤之～，确诊癌患者的治疗效果。为改善中晚期肝癌患者的预后，时多处于中晚期，治疗具有相当难度。肝动脉化疗栓寻找新的有效治疗手段的要求日益迫切[2]。I是塞术(transcatheterarterialchemoemboliz