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时间:2020-05-07
《抗病毒治疗在肝癌治疗中应用与评价-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、708·中国实用外科杂志2014年8月第34卷第8期I91NishidaS,IeviDM,TzakisAG.Livernaturelkillereellinocu—autologousdendriticcellvaccineinpatientswithadvancedlureforlivertransplantationwithhepatocellularcarcinomalJ].HCC[Jj.JCancerResClinOncol,2013,139(1):39-48.Cure"OpinOrganTransplant,2013,18(6):690-694.【24]Oh
2、iraM,IshiyamaK,TanakaY,etalAdoptiveimmunnthera—110]OhiraM,NishidaS,TryphonopoulosP,eta1.Clinical—scalePYwithliverallngraft—derivedlymphocytesinducesanti——HCVisolationofinterleukin一2一stimulatedlivernaturalkillercellsactivityafterlivertransplantationinhumansandhumanizedfortreatmentofliver
3、transplantationwithhepatocellularcaret—miee[J].JClinInvest,2009,119(11):3226-3235.nomaI3j.CellTransplant,2012,21(7):1397—406.(2014—05—05收稿)[11jVillanuevaMT.Immunothcrapy:Killingwithnaturalkillers,naturallylJjNatRevClinOncnl,2014,11(4):l80.文章编号:1005—2208(2014)08—0708—03112]HumphriesC.Ado
4、ptivecelltherapy:HoningthatkillerinstinctDOI:10.7504/CJPS.ISSN1005—2208.2014.08.10lJj.Nature,2013,504(7480):S13-S15.[13]ParkhurstMR,YangJc,LanganRC,ctalTcellstargetingcar—cinoemhryonicantigencanmediateregressionofmetastatic抗病毒治疗在肝癌治疗中eololeetalcancerhillinduceseverelransienlcolitislJJ.M
5、ol应用与评价Thor,20I1,19(3):620—626.[14]RohhinsPF,MorganRA,FehhnanSA,eta1.Tumorregression周伟平,黄罡,王若愚,吴孟超inpatientswithmetastaticsynovialcellsarcomaandmelanomausinggeneticallyengineeredlymphocytesreactivewithNY—ESO~1lJJ.JClinOntol,20l1,29(7):917-924.【摘要】乙肝病毒(HBV)感染是我国肝细胞癌(HCC)发生[15]Kah)sM,Levi
6、neBL,PorterDL,eta1.Tcellswithchimerican—的最主要致病因素,应重视并积极治疗。长期抗病毒治疗tigenreceptorshavepotentanlitumoreffectsandcanestahlish可有效抑制HBV复制和再激活,降低HCC病人手术及肝动memoryinpatientswithadvancedleukemialJ].sciTransl脉化疗栓塞(TACE)后肝功能衰竭发生率,减轻肝脏炎症,Med.20l1.3(95):95ra73.改善肝纤维化,降低手术后远期复发率,明显提高总存活ll6]BrentjensRJ,
7、DavilaML,RiviereI,eta1.CD19-targetedT率。抗病毒应答时间、病毒耐药变异等均是影响HCC术后cellsrapidlyinducemolecularremissionsinadultswithchemo一复发的危险因素。因此,选择速效、低耐药核苷类药物非[herapy—refractoryacutelymphoblasticleukemia[J].Sci常重要。由于HCC病人术后复发率高,常需反复进行手TranslMef1.2013.50771:177ra38.术、TACE、放疗、消融等治疗,易引起HBV再激活,故主张
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