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时间:2020-05-07
《恩替卡韦联合异甘草酸镁治疗慢性乙肝患者临床观察-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·856·中国热带医学2014年第14卷第07期ChinaTropicalMedicine,July2014,Vo1.14,No.07·论著·恩替卡韦联合异甘草酸镁治疗慢性乙肝患者临床观察倪传斌,李三清,陈武军三亚市解放军四二五医院感染科,海南三亚572000摘要:目的观察恩替卡韦联合异甘草酸镁治疗慢性乙型肝炎患者肝组织病理学的临床变化。方法自2010年4月一2013年8月,收集慢性乙型病毒性肝炎患者70例,随机分为治疗组及对照组各35例,治疗组口服恩替卡韦0.5mg/d、1次/d,同时用异甘草酸镁注射液150mg静脉滴注,1次,d
2、;对照组口服恩替卡韦O.5ms/d、1次/d,疗程为12周,记录两组治疗前后肝组织炎症活动度、肝纤维化程度及血清肝纤维化指标水平,并对两组治疗前后的数据进行统计学分析。结果治疗结束后,两组肝组织炎症活动度(U=433)、肝纤维化程度(U=426.5)相比较差异均有统计学意义(P3、度及肝纤维化程度,降低血清肝纤维化指标,优于单用恩替卡韦,值得临床推广。关键词:恩替卡韦;异甘草酸镁;慢性乙型肝炎;肝组织病理学中图分类号:R512.62文献标识码:A文章编号:1009—9727(2014)7—856~03PathologicaIchangesofIivertissueinchronichepatitisBpatientstreatedwithcombinationtherapyofentecavirandmagnesiumlSOgIycyrrhizinateNIChuan—bin,LISan—qing,CHENW4、u-junDepartmentofInfectiousDiseases,No.425HospitalofPLA,Sanya572OOO,Hainan,P.R.ChinaAbstract:ObjectiveToobservethepathologicalchangesoflivertissueinchronichepatitisBpatientsaftercombinationtherapywit}lentecavirandmagnesiumisoglycyrrhizinate.MethodsTotally70chronichepat5、itisBpatientswereenroUedfromApril2010toAugust2013andrandomlydividedintoexperimentalgroupandcontrolgroup(35casesineachgroup).Patientsinexperimentalgrouptookentecavir0.5mg/dqdorallyandmagnesiumisoglycyrrhizinate150mgqdintravenously.Thepatientsincontrolgrouponlytookenteca6、virorally.Beforeand12weeksaftertreatment,thedegreeoflivertissueinflammation,fibrosisandserummarkeroffiverfibrosiswereobservedandstatisticallyanalyzed.ResultsAftertreatment,thereweresignificantdifferences(19<0.05)betweenthetwogroupsintermsoflivertissueinflammation(U=4337、)andfibrosis(U=426.5).Withregardtotheserummarkerofliverfibrosis,suchashyalumnicacid(t=-10.7),typeIIIprocoUagen(t=8.48),typeIVcoUagen(t=-6.7)andlaminin(t=-5.3),thereweresignificantdiferencesbetweenthetwogroups,tooCP<0.01).ConclusionComparedwithsingledrugtherapyofentecav8、ir,entecavircombinedwithmagnesiumisoglycyrrhizinatesignificantlyreducedthedegreeoflivertissueinflammation,fibrosisand
3、度及肝纤维化程度,降低血清肝纤维化指标,优于单用恩替卡韦,值得临床推广。关键词:恩替卡韦;异甘草酸镁;慢性乙型肝炎;肝组织病理学中图分类号:R512.62文献标识码:A文章编号:1009—9727(2014)7—856~03PathologicaIchangesofIivertissueinchronichepatitisBpatientstreatedwithcombinationtherapyofentecavirandmagnesiumlSOgIycyrrhizinateNIChuan—bin,LISan—qing,CHENW
4、u-junDepartmentofInfectiousDiseases,No.425HospitalofPLA,Sanya572OOO,Hainan,P.R.ChinaAbstract:ObjectiveToobservethepathologicalchangesoflivertissueinchronichepatitisBpatientsaftercombinationtherapywit}lentecavirandmagnesiumisoglycyrrhizinate.MethodsTotally70chronichepat
5、itisBpatientswereenroUedfromApril2010toAugust2013andrandomlydividedintoexperimentalgroupandcontrolgroup(35casesineachgroup).Patientsinexperimentalgrouptookentecavir0.5mg/dqdorallyandmagnesiumisoglycyrrhizinate150mgqdintravenously.Thepatientsincontrolgrouponlytookenteca
6、virorally.Beforeand12weeksaftertreatment,thedegreeoflivertissueinflammation,fibrosisandserummarkeroffiverfibrosiswereobservedandstatisticallyanalyzed.ResultsAftertreatment,thereweresignificantdifferences(19<0.05)betweenthetwogroupsintermsoflivertissueinflammation(U=433
7、)andfibrosis(U=426.5).Withregardtotheserummarkerofliverfibrosis,suchashyalumnicacid(t=-10.7),typeIIIprocoUagen(t=8.48),typeIVcoUagen(t=-6.7)andlaminin(t=-5.3),thereweresignificantdiferencesbetweenthetwogroups,tooCP<0.01).ConclusionComparedwithsingledrugtherapyofentecav
8、ir,entecavircombinedwithmagnesiumisoglycyrrhizinatesignificantlyreducedthedegreeoflivertissueinflammation,fibrosisand
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