低分子肝素联合依达拉奉治疗进展型脑梗死的疗效观察-论文.pdf

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1、8·论著·January2014，Vo1．12，No．1低分子肝素联合依达拉奉治疗进展型脑梗死的疗效观察尹魁明(山东昌邑市人民医院神经内二科，山东昌邑261300)【摘要】目的探讨依达拉奉和低分子肝素(LMWH)联合治疗急性进展型脑梗死的疗效。方法将160例急性进展型脑梗死患者随机分为联合治疗组和对照组各80例。2组患者在常规治疗的基础上均给予LMWH5000U腹部皮下注射，每12h1次。连用14d。联合治疗组再给予依达拉奉30mg加入生理盐水100mL静脉滴注，每天2次，连用10d。分别于治疗前和治疗后进行神经功能缺损程度评分(NDS)及凝血功能检查。结果联合治疗

2、组的总有效率(85％)明显高于对照纽(65％)<0．O5)；2组治疗后NDS改善显著0．O5)。联合治疗组出现轻度血转氨酶1例、尿素氮升高2例，未经相应治疗，均短期内恢复正常。结论依达拉奉联合LMWH治疗急性进展型脑梗死效果显著，有助于改善神经功能，无明显不良反应。【关键词】依达拉奉；低分子肝素；脑梗死，急性进展型中图分类号：R743．3文献标识码：B文章编号：1671-8194(2014)01—0008—03TherapeuticEfectsofEdaravoneandLowMolecularW

3、eightHeparinonPatients、vithAcuteProgressiveCenrebradInfarctionYINKui—ming(No．2DepartmentofNeurology,ChangyiPeople'sHospital,Changyi261300，China)IAbstract]ObjeetiveToinvestigatethetherapeuticeffectofedaravoneandlowmolecularweightheparin(LMWH)onacuteprogressivecerebralinfarction．MethodsC

4、onsecutive160patientswithacuteprogressivecerebralinfarctionwererandomlydividedintouniontherapygroup(n=80)andcontrolgroup(n=80)．Thepatientsinbothtwogroupsunderwentconventionaltreatment．andwereadministratedlowmolecularweightheparin5000Usubcutaneousinjectionatabdomen，onetimeevery12hours，l

5、astedfor14d．Inuniontherapygroup，patientswereaddedwithedaravone(30mgintravenously，twiceperday，lastedfor10d)．Theneurologicalfunctionaldificitscore(NDS)andclottingfunctiontestswereexaminedandcomparedbetweenpreandposttreatment．ResultsThetotalefectivemteinuniontherapygroup(85％)Wagsignifican

6、tlyhigherthanthatinthecontrolgroup(65％)(P0．05)aftertreatment．IntheUniontherapygroup，therewerelcasewithl

7、ivertransaminasesmildlyelevated，2casewithbloodureanitrogenelevated．Thecomplicationdismissedafterwithoutappropriatetreatmentinshortterm．ConclusionItdemonstratedthatcombinationedaravonewithlow—molecularweightbepafinontreatingacuteprogressivecerebralinfarctionhadbetterthempouticefect，an