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时间:2020-05-07
《抑郁情绪对冠心病患者 CRP及低密度脂蛋白水平的影响-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·780中国医师杂志2014年6月第l6卷第6期JournalofChinesePhvsician。June2014。Vo1.16,No.6·论著·抑郁情绪对冠心病患者CRP及低密度脂蛋白水平的影响袁宝鸿【摘要】目的探讨抑郁情绪对冠心病患者血清炎症因子C一反应蛋白(CRP)和低密度脂蛋白水平(LDL)的影响。方法选取本院接诊的有、无抑郁情绪的冠心病门诊或住院患者各40例;选取同期在本院体检的无冠心病的健康体检者20例为对照组。测量比较三组血清CRP、LDL水平,并分析抑郁量表评分与CRP、LDL的相关性。结果抑郁冠心病患者抑郁自评量表(SDS)[(46.22
2、±3.90)分]、汉密尔顿抑郁量表(HAMD)[(24.39±3.08)分]评分均明显高于对照组[(22.46±6.22)分、(10.36±4.22)分]及非抑郁冠心病组患者[(29.36±5.34)分、(10.30±4.11)分](P<0.05),而对照组和非抑郁冠心病组间SDS、HAMD量表评分差异无统计学意义(P>0.05);抑郁冠心病患者CRP[(24.36±3.25)mg/L]、LDL[(2.85±1.42)mmol/L]水平均明显高于对照组及非抑郁冠心病组患者(P<0.05),非抑郁冠心病患者的CRP、LDL水平明显高于对照组(P<0.05);S
3、DS、HAMD量表评分与CRP、LDL、心率呈正相关(P<0.05)。结论冠心病患者保持轻松乐观的心态,对于改善冠心病的治疗效果具有促进作用。[关键词]抑郁;冠心病;C反应蛋白质/代谢;脂蛋白类,LDL/JfⅡ液EfectsofdepressiononC-reactiveproteinandlow-densitylipoproteinlevelsinpatientswithcoronaryarterydiseaseYuanBaohong.DepartmentofInternalMedicine,BeringShuiliHospital,Beng100036,
4、China【Abstract】0bjectiveToinvestigateeffectsofdepressiononC-reactiveprotein(CRP)andlowdensitylipoprotein(LDL)levelsinpatientswithcoronaryarterydisease.MethodsEightycoronaryheartdiseasepatientswithandwithoutdepressionand20coronaryheartdisease—freecaseswereselected,CRPandLDLlevelswer
5、emeasuredandcomparedamongthreegroups.TheeOH’elationofdepressionscoreswithCRPandLDLwereanalyzed.ResultsDepressionselfratingscale(SDS),andHanfihonDepressionScale(HAMD)scoresofpatientswithcoronaryheartdisease(CHD)+depressionwere46.22±3.90,and24.39±3.08,whichweresig—nificantlyhighertha
6、ncontrolgroup(22.46±6.22,10.36±4.22)andnon—depressedCHDpatients(29.36±5.34,and10.30±4.11)(P<0.05),respectively.Therewerenosignificantdifferencebetweencontrolgroupandnon—depressedCHDpatientsforSDSandHAMDscores(P>0.05).CRPandLDLlevelsofpatientswithCHD+depressionwere(24.36±3.25)m#L,(2
7、.85±1.42)mmol/L,whichweresignificantlyhigherthancontrolgroupandnon—depressedCHDpatients(P<0.05).CRPandLDLlev—elsofnon—depressedCHDpatientswerehigherthancontrolgroup(P<0.05).SDS,andHAMDscoreshadapositivecorrelationwithCRP,LDL,andheartrate(P<0.05).ConclusionsCHDpatientsshouldrenmin0p
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