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时间:2020-05-07
《原发性肝癌合并门静脉高压症病人行联合肝脾切除与单纯肝切除的回顾性研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·284·腹部外科2014年第27卷第4期FuBuWaiKe,Aug.2014,Y.!!:·论著·(临床实践)原发性肝癌合并门静脉高压症病人行联合肝脾切除与单纯肝切除的回顾性研究罗鸿萍王其张必翔[摘要]目的探讨脾切除在合并轻中度乙型病毒性肝炎(简称乙肝)后肝硬化性门静脉高压症的原发性肝癌病人中的作用。方法选取2002~2008年间符合下列条件的171例合并乙肝肝硬化性门静脉高压症的原发性肝癌病人进行回顾性对照研究:①术前血小板计数在50X10’/L-80×109/L之间,白细胞计数>2.0X10/L;②
2、无食管静脉曲张或曲张程度≤F2;③肿瘤病灶经术前评估可切除。按是否接受同时陛脾切除将病例分为联合肝脾切除组(SPH)及单纯肝切除组(HA),前者57例,后者114例。结果两组病例在围手术期临床资料等方面差异无统计学意义(P>O.05)。脾切除对肝功能有短期改善作用,长期则无影响;对无瘤生存率(HA26.3、SPH35.1)及总生存率(51.8与54.4)无明显影响(P>O.05)。严重并发症发生率联合肝脾切除组病人(22.8)较单纯肝切除组(7.9%)高(P3、静脉高压症的原发性肝癌病人,脾切除并无必要性,应慎行之。[关键词]肝硬化;肝肿瘤;脾切除术[中图分类号]R657.34[文献标示码]A[DOI]10.3969/j.issn.1003—5591.2014.04.012CasecontrolledstudyofsimultaneoushepatectomyandsplenectomyversushepatectomyaloneinpatientswithchronichepatitisB-relatedhepatocellularcarcinomaandp4、ortalhypertensionLuoHongping,WangQ,ZhangBixiang.HepaticSurgeryCenter,Tongji&Hospital,YongjiMedicalCollege,HuazhongUniversity0,’Science&Technology,Wuhan430030,CinaCorrespondingauthor:Wang,Email:zmngki2004@126.COrn[Abstract]ObjectiveToexploretheoutcomesofs5、imultaneoussplenectomyandhepatectomy(SPH)versushepatectdmy(HA)aloneinpatientswithhepatitisB-relatedhepatocellularcarcinomaandportalhypertension(HBV-HCC/PH).MethodsAretrospectivecasecontrolstudywasconduc—tedfor171HBV-HCC/PHpatients.Theinclusioncriteriainc6、luded:①plateletcountshadarangeof50X10/Lto8OX10/Landwhitebloodcellcountwas>2.0×10/L;②absenceofesophagealvar—icesorvarices≤F2;③undergoingeitherSPHorH八TheyweredividedintoSPH(n=57)andHA(=114)groups.ResultsTheperioperativeclinicalcharacteristicsoftwogroupswer7、enotstatistical—lydifferent.ComparedtotheHAgroup,theSPHgrouphadtransientlyimprovedpostoperativeliverfunctionandlong—termamelioratedthrombocytopenia,buthigherratesofmajorpostoperativecompli—cations.Splenectomyhadnoeffectontumor-freeoroverallsurviva1.Conel8、usionsInpatientswithHI,_HCC/PH,splenectomyiSassociatedwithtransientlyimprovedliverfunctionandmorefrequentmajorpostoperativecomplications.ButitiSunnecessaryforthosewithmildpancytopeniaand
3、静脉高压症的原发性肝癌病人,脾切除并无必要性,应慎行之。[关键词]肝硬化;肝肿瘤;脾切除术[中图分类号]R657.34[文献标示码]A[DOI]10.3969/j.issn.1003—5591.2014.04.012CasecontrolledstudyofsimultaneoushepatectomyandsplenectomyversushepatectomyaloneinpatientswithchronichepatitisB-relatedhepatocellularcarcinomaandp
4、ortalhypertensionLuoHongping,WangQ,ZhangBixiang.HepaticSurgeryCenter,Tongji&Hospital,YongjiMedicalCollege,HuazhongUniversity0,’Science&Technology,Wuhan430030,CinaCorrespondingauthor:Wang,Email:zmngki2004@126.COrn[Abstract]ObjectiveToexploretheoutcomesofs
5、imultaneoussplenectomyandhepatectomy(SPH)versushepatectdmy(HA)aloneinpatientswithhepatitisB-relatedhepatocellularcarcinomaandportalhypertension(HBV-HCC/PH).MethodsAretrospectivecasecontrolstudywasconduc—tedfor171HBV-HCC/PHpatients.Theinclusioncriteriainc
6、luded:①plateletcountshadarangeof50X10/Lto8OX10/Landwhitebloodcellcountwas>2.0×10/L;②absenceofesophagealvar—icesorvarices≤F2;③undergoingeitherSPHorH八TheyweredividedintoSPH(n=57)andHA(=114)groups.ResultsTheperioperativeclinicalcharacteristicsoftwogroupswer
7、enotstatistical—lydifferent.ComparedtotheHAgroup,theSPHgrouphadtransientlyimprovedpostoperativeliverfunctionandlong—termamelioratedthrombocytopenia,buthigherratesofmajorpostoperativecompli—cations.Splenectomyhadnoeffectontumor-freeoroverallsurviva1.Conel
8、usionsInpatientswithHI,_HCC/PH,splenectomyiSassociatedwithtransientlyimprovedliverfunctionandmorefrequentmajorpostoperativecomplications.ButitiSunnecessaryforthosewithmildpancytopeniaand
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