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《亚低温与神经干细胞移植干预缺血缺氧性脑病叠加的神经保护作用.doc》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、亚低温与神经干细胞移植干预缺血缺氧性脑病：叠加的神经保护作用神经干细胞移植可用于治疗缺血性脑卒中，但移植后的神经干细胞在缺血缺氧大脑微环境中常出现凋亡，而亚低温疗法具有强大的神经保护作用，来自中国上海交通大学的王林所在团队构想了以亚低温（27–28°C）联合神经干细胞移植（1.0×105/μL）共同干预缺血缺氧性脑病，会得到更好的神经保护作用的设计。在实验中发现亚低温联合神经干细胞移植效果优于单独应用亚低温或神经干细胞移植治疗的效果，其作用可能通过抗炎和抗凋亡的多重途径来实现。文章发表在《中国神经再生研究（英文版）》杂志2014年10月第19期。Article
2、:"Mildhypothermiacombinedwithneuralstemcelltransplantationforhypoxic-ischemicencephalopathy:neuroprotectiveeffectsofcombinedtherapy,"byLinWang,FengJiang,QifengLi,XiaoguangHe,JieMa(DepartmentofPediatricNeurosurgery,XinhuaHospitalofShanghaiJiaotongUniversity,Shanghai200092,China)WangL
3、,JiangF,LiQF,HeXG,MaJ.Mildhypothermiacombinedwithneuralstemcelltransplantationforhypoxic-ischemicencephalopathy:neuroprotectiveeffectsofcombinedtherapy.NeuralRegenRes.2014;9(19):1745-1752.欲获更多资讯：NeuralRegenResMildhypothermiaandNSCstransplantationprotectagainsthypoxic-ischemicencepha
4、lopathyNeuralstemcells(NSCs)transplantationisausefultreatmentforischemicstroke,butapoptosisoftenoccursinthehypoxic-ischemicenvironmentofthebrainaftercelltransplantation.WangLinandhiscolleagues,ShanghaiJiaotongUniversity,China,hypothesizedthatmildhypothermia(27–28°C)combinedwithNSCs(
5、1.0×105/μL)transplantationexhibitbetterneuroprotectiveeffectsonhypoxic-ischemicencephalopathythanmonotherapy.TheirexperimentalresultsconfirmthatmildhypothermiacombinedwithNSCstransplantationissuperiortomonotherapyinthetreatmentofhypoxic-ischemicencephalopathy,andtheneuroprotectiveef
6、fectsareachievedthroughanti-inflammatoryandanti-apoptoticmechanisms.TherelevantstudyhasbeenpublishedinNeuralRegenerationResearch(Vol.9,No.19,2014).Article:"Mildhypothermiacombinedwithneuralstemcelltransplantationforhypoxic-ischemicencephalopathy:neuroprotectiveeffectsofcombinedthera
7、py,"byLinWang,FengJiang,QifengLi,XiaoguangHe,JieMa(DepartmentofPediatricNeurosurgery,XinhuaHospitalofShanghaiJiaotongUniversity,Shanghai200092,China)WangL,JiangF,LiQF,HeXG,MaJ.Mildhypothermiacombinedwithneuralstemcelltransplantationforhypoxic-ischemicencephalopathy:neuroprotectiveef
8、fectsofcombinedther
