参龟保肝升白蛋白丸对肝纤维化大鼠形态学及组织病理学的影响-论文.pdf

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1、人参研究GINSENGRESEARCH2014年第1期参龟保肝升白蛋白丸对肝纤维化大鼠形态学及组织病理学的影响徐华丽陈俊俊于晓风曲绍春王志才陈燕萍z睢大贳水(1．吉林大学药学院药理教研室·吉林长春·130021；2．吉林大学化学学院天然药物化学研究室·吉林长春·130021)摘要：目的建立大鼠实验性肝纤维化模型，观察参龟保肝升白蛋白丸对大鼠形态学及组织病理学的影响。方法将Wistar大鼠随机分为对照组、模型组、阳性药物组及参龟保肝升白蛋白丸0．5、1和2组。皮下注射CCI4花生油溶液l0周建立大鼠实验性肝纤维化模型，参龟保肝升白蛋白丸连续给药4周后观

2、察大鼠一般状况、肝脏系数、肝组织大体形态及病理学变化。结果与模型组比较，参龟保肝升白蛋白丸中、大剂量组大鼠一般状态良好，肝脏系数显著降低(P

3、henguibaoganshengbaidanbaiPillonmorphologyandhistopathologyinhepaticfibrosisratsXUHua-liCHENJun-jun。YUXiao-fengQUShao-chun。WANGZhi-caiCHENYah-pingaSUIDa-yun．DepartmentofPharmacology,SchoolofPharmacy,JilinUniversity,Changchun130021，China；2Departmentofnaturalmedicinalchemistry,Sc

4、hoolofChemistry,JilinUniversity,Changchun130021Abstract：Objective：ToinvestigatetheprotectiveefectoftheShenguibaoganshengbaidanbaiPill0nthecarbontetraehloride(CC14)inducedexperimentalhepaticfibrosisinrats．Methods：CC14wasinjectedfor10weekstoinduceliverfibrosisinWistarrats．After10

5、weeks，theWistarratswererandomdividedintofivegroups：modelgroup，positivedruggroupandShenguibaoganshengbaidanbaipillgroups(0．5，1．0and2．0gCkg)．Thoseratsweregivendrugsfor4weeks．Duringtheexperimentthegeneralappearancewasobserved．After4weeks，theratsweresacrificedandtheliverwastakenfor

6、mowholo~andhistopathologyexamination．Results：Compamdwiththemodelgroup，thegeneralappearanceinShenguibaoganshengbaidanbaipillgroups(1．0and2．0s／ks)wasbetter．ThecoeficientofliverinShenguibaoganshengbaidanbaipillgroups(1．0and2．0g／kg)wasalsolowerthanthoseinthemodelgroup．IntheShenguib

7、aoganshengbaidanbaiPillgroups，hepaticcellsdegenerationandnecrosiswasinslightextent，andtheextractfacilitatedtheregenerationofthehepatocyte，andretardedtheformingofliverfibrosis．Conclusion：ShenguibaoganshengbaidanbaipillCandefinitelypreventliverfibrosis．Keywords：Shenguibaogansheng

8、baidanbaipill；Hepaticfibrosis；Histopathology；Rats基金项目：