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时间:2020-05-04
《序贯联合超声指数改善瞬时弹性成像诊断代偿性乙肝肝硬化-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、·40·中华超声影像学杂志2014年1月第23卷第1期ChinJUltrasonogr,January2014,Vol23,No.1——.临床研究·序贯联合超声指数改善瞬时弹性成像诊断代偿性乙肝肝硬化戴琳尹军花冯筱榕卢燕薇张琪梁携儿朱幼芙陈永鹏【摘要】目的探讨超声指数诊断代偿期乙肝肝硬化有效性及序贯联合应用超声指数改善瞬时弹性成像(TE)技术对代偿期乙肝肝硬化的诊断效能。方法回顾性分析222例肝活检代偿性慢性乙型肝炎患者资料,记录患者血液常规、血生化指标、凝血功能指标、超声检查肝胆脾及TE检查结果,并进行统计学分析,评价诊断效能。结果肝硬化及非肝
2、硬化患者年龄、胆红素、凝血功能国际标准化比率、血小板、肝硬度值及超声指数差异均有统计学意义,对肝硬化均有诊断效能,以TE、超声指数诊断效能最高[ROC曲线下面积0.896(0.855—0.937)对0.852(0.793—0.911),Z=1.30,P=0.1936],两者差异无统计学意义;TE可使65.8患者确定有或无肝硬化而免于肝活检,明显高于超声指数(41.9);序贯联合TE及超声指数可使78.0明确肝硬化状态的患者免于肝活检。结论由肝胆脾超声指标及年龄构成的超声指数可有效诊断或排除代偿期乙肝肝硬化,同时可作为补充诊断方法提高TE的诊断效能
3、。【关键词】超声检查;乙型肝炎,慢性;肝硬化;瞬时弹性成像StepwisecombinationwithultrasonicindeximprovingperformanceoftransientelastographydetectingcompensatedchronichepatitisBcirrhosisDaiLin,YinJunhua,FengXiaorong,L“Yanwei,ZhangQi,LiangXieer,ZhuYoufu,ChenYongpeng.DepartmentofInfectiousDisease,NanfangHos
4、pital,SouthernMedicalUniversity,Guangzhou510515,ChinaCorrespondingauthor:ChenYongpeng,Email:cyp@smu.edu.cn[Abstract]0bjectiveToinvestigatethevalidityofultrasonicindex(USI)indetectingcompensatedhepatitisBcirrhosisandtheimprovementofdetectingcirrhosisbystepwisecombinationoftran
5、sientelastography(TE)andUSI.MethodsTotalof222patientswithcompensatedhepatitisBundergoneliverbiopsieswereretrospectivelyinvestigated.Patientshematology,serumbiochemicalindex,coagulationindex,TEandultrasonographyofliver,gallbladderandspleenwerestatisticallyanalyzedtoevaluatethe
6、diagnosticefficiency.ResultsTherewerestatisticaldifferencesbetweenpatientswithandwithoutcirrhosisinage,serumbilirubin,internationalnormalizedratio,platelet,liverstiffnessandUSI,whichcouldefficientlydetectcirrhosis.Amongthem,TEandUSIdiscriminatedcirrhosiswithhigherareaunderR0C
7、swithoutstatistica1differenceEo.896(O.855—0.937)VS0.852(0.793—0.911),Z=1.30,P=0.1936].WhileTEclassified65.8ofpatientsascirrhosisornon-cirrhosisandfreedthemfrom1iverbiopsies,thisnumberdecreasedto41.9inUSI,stepwisecombinationofTEandUSIimprovedthisnumberupto78.0.ConclusionsUSIco
8、nsistingofageandu1trasonographyofliver,gallbladderandspleenwasvalida
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