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时间:2020-05-03
《IL-10在骨髓间充质干细胞分泌的因子逆转急性肝衰竭中的作用-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、t枣华^溱化泰恚’⑩世界华人消化杂志201:3年12月8Fq;21(34):3783—3789wcjd@wjgnet.cornISSN1009—3079(print)ISSN2219—2859(online)
2、拍严岩劂殿捌遁雕IL一10在骨髓间充质干细胞分泌的因子逆转急性肝衰竭中的作用雷延昌,梁青,罗盼,李雯雷延昌,梁青,罗盼,李雯,南昌大学附属感染病医院江西省MSC—CMplusIL一10antibodygroup.Kaplan—■背景资料南昌市330006国内外合作者研Meiermethodwasusedforsurviva1analysis.雷延昌,主任医师,主要从事病毒性肝炎
3、和肝衰竭发病机制的研究究显示骨髓间充江西省科技支撑基金资助项目,No.2009JX00916SerumalaninetransaminasefALT1andaspar—质干细胞分泌南昌市科技局重点基金资助项目,No.洪财政[2012137号社tateaminotransferasefAST)levelsweredetected的因子fmesen—会发展支撑计划一10atdifferenttimepoints,livertissuepathologicalchymalstemcell—作者贡献分布:课题设计由雷延昌主持:研究过程由粱青、罗盼derivedmolecules,change
4、swereexaminedafter24h,andihighmo—及李雯实施:论文写作由雷延昌完成.MSC—CM)减轻急通讯作者:雷延昌,主任医师,330006,江西省南昌市洪都中大bilitygroupbox1(HMGB1),IL一1p,tumornecro—性肝衰竭小鼠肝道167号南昌大学附属感染病医院ycleihust@sinacomsisfactor仅(TNF一)andIL-10weredetectedby脏炎症坏死和促电话:0791—88499615EIISA.进肝细胞再生,其收稿日期:2013—1O一30修回日期:2013—11—17中重要抗炎因子接受日期:2013—11
5、—27在线出版日期:2013—12一D8白介素一10(inter.RESULTS:Thesurvivalratewassignificantly1eukin—l0.IL.1O、higherintheMSC—CMtreatmentgroupthanin的水平升高显著,Mesenchymalstemcell-theALFgroup(88.9%vs39%,P<0.0L).MSC-但IL.1O在治疗急derivedmoleculesattenuateCMtreatmentdecreasedALT/ASTlex,elsat12,性肝衰竭中的作用尚不清楚.mouseacutelivefailur
6、ebyup·24and48hmoresignificantlycomparedwithregulatingIL-10theALFgroup(allP<0.01).SerumHMGB1at6,12,and24h,andTNF一仪andIL一1Bat24hwerealsodecreasedsignificantlyintheMSC—CMYan-ChangLei,QingLiang,PanLuo,WenLitreatmentgroupfallP<0.01),however,IL一101evelwasincreasedsignificantlyintheMSC。Yan-ChangLeilQi
7、ngLianglPanLuo
8、WenLilInfec—tiousDiseasesHospita1ofNanchangUniversity,NanchangCMtreatmentgroup(P<0.011.Theinflamma—330006。JiangxiProvince,ChinationandnecrosisinlivertissuesweremitigatedSupportedby:theFoundationofJiangxiScienceandmoresignificantlVintheMSC—CMtreatmentTechnologyDepartment.No.2009JX
9、0096;andtheFounda—tionofNanchangScienceandTechnologyDivision,No.groupthanintheALFgroup(P<().01).In2012—37—10MSC.CMtreatedmiceadministrationofIL.1OCOrresDOndenceto:Yan—ChangLei,ChiefPhysician,antibodyneutralizedthetherapeuticeffect
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