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时间:2020-05-02
《利伐沙班预防老年髋关节置换术后下肢静脉血栓的临床疗效及安全性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、762中国临床药理学杂志第30卷第9期2014年9月(总第179期)李庄汝l坚2未一曾利伐沙班预防老年髋关云节置换术后下肢静脉汜血栓的临床疗效及安全性研究谢Eficacyandsafetyofrivaroxabaninthepreventionofdeepveinthrombosisin佥勉patientswithhiparthroplasty摘要:目的评价利伐沙班预防老年髋关节置换术后下肢静脉血栓的临床疗效及安全性。方法收治行单侧髋关节置换术的老年患者98例,随机分为利伐沙班组(46例)和低分子肝素组(52例),分别于
2、术后6h口服利伐沙班10mg·d~,连续5周;皮下注射低分子肝素4100U,连续2周。观察2组患者术后6个月下肢静脉血栓发生风险。结果术后随访6个月,利伐沙班组和低分子(1.杭州师范大学附属医院骨科,杭州肝素分别有2,4例失访脱落。利伐沙班组与低分子肝素组下肢静脉血栓发生率310015;2.浙江省中医院骨科,杭州310006)分别为2.3%(1/44)和14.6%(7/48),利伐沙班组显著低于低分子肝素组(P<0.05);但2组患者术后血小板计数、凝血功能、引流量及皮下瘀斑面积差别无统计学意义(P>0.05)。结论利伐
3、沙班可有效降低老年髋关节置换术后下肢静L1Jian,CENGYun—ji,脉血栓发生风险,且无明显不良反应。XIEJin—tu,ZHUANGRu—jie关键词:利伐沙班;髋关节置换术;下肢静脉【In栓;低分子肝素DOI:10.13699/j.cnki.1001—6821.2014.09.003中图分类号:R619.2;R973.2文献标志码:A(,.DepartmentofOrthopedics,The文章编号:1001—6821(2014)09—0762—03AffiliatedHospitalofHangzhouNo
4、rmalUniversity,Hangzhou310015,China;Abstract:ObjectiveToinvestigatetheeficacyandsafetyoffivaroxa—2.DepartmentofOrthopedics,TheTra—baninthepreventionofdeepveinthrombosisinpatientswithhiparthro—ditionalHospitalofZhejiangProvince,plasty.MethodsNinety—eightpatientswi
5、thhiparthroplastywerere—Hangzhou31O006,China)cruitedinourhospita1.Theincluded98caseswererandomizeddividedintorivaroxabangroup(n=46)withrivaroxaban10mg·dorallywith5一weekandlowmolecularheparin(LMH)groupwithLMH4100Uwith2一week.Theriskofdeepveinthrombosisbetweenthetwo
6、groupswasrecordedwithintheflowing6months.ResultsWithafollow—upperi-0dof6months.theincidenceofdeepveinthrombosiswere2.3%(1/44)and14.6%(7/58)intherivaroxabangroupandLMHgroupre—spectively,whichindicatedtheincidencewasmuchlowerinrivaroxabangroup(P<0.05).Buttheplatele
7、tcount,coagulationfunction,drainagevolumeandsubcutaneousecchymosiswerenotdifferentbetweenthetwogroups(P>0.05).ConclusionRivaroxabancansignificantdecrease收稿日期:2014—05—04theriskofdeepveinthrombosisinpatientswithhiparthroplastywithout修回日期:2014—07—25increasingtheside
8、effects.基金项目:浙江省科技厅创新基金资助项目Keywords:rivaroxaban;hiparthroplasty;deepveinthrombosis;low(2OllR50022—04)作者简介:李坚(1977一),男,主治医师,主要molecularheparin从事退行性骨关节病及创伤研究通信作者
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