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时间:2020-05-02
《双歧杆菌四联活菌片对急性胰腺炎患者血清内毒素和降钙素原水平的影响及疗效观察.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、中国微生态学杂志2014年6月第26卷第6期ChineseJournalofMicroecology,Jun.2014,Vo1.26No.6671·临床研究·双歧杆菌四联活菌片对急性胰腺炎患者血清内毒素和降钙素原水平的影响及疗效观察王卫强,陈涵清1.急诊科;2.消化科,临海市第二人民医院,浙江临海317016摘要:目的探讨双歧杆菌四联活菌片对急性胰腺炎患者血清内毒素和降钙素原(PCT)水平的影响及疗效观察。方法将66例急性胰腺炎患者随机分为观察组和对照组。两组患者均予以禁食禁饮、持续胃肠减压、预防感染、抑酸、解
2、痉镇痛、抑制胰酶分泌和纠正水电解质酸碱紊乱等常规治疗。观察组患者加用双歧杆菌四联活菌片1.5g进行水化后自胃管灌注,夹管2h,3次/d,对照组除不使用双歧杆菌四联活菌片外余治疗同观察组。观察两组患者治疗前后血清内毒素和PCT水平的变化,并比较其临床疗效。结果治疗7d后,两组患者血清内毒素和PCT水平均有不同程度的下降(P<0.05或P<0.01),且观察组下降值比对照组更明显(P<0.05);同时观察组临床总有效率为93.94%,明显高于对照组的75.76%(X2=4.24,P<0.05)。结论双歧杆菌四联活菌
3、片辅助治疗急性胰腺炎具有较好疗效,能明显降低血清内毒素和PCT水平,减轻肠源性内毒素血症,对肠黏膜屏障功能具有良好的保护作用。关键词:急性胰腺炎;双歧杆菌四联活菌片;肠黏膜屏障中图分类号:R587文献标志码:A文章编号:1005—376X(2014)06-0671-03DOI编码:10.13381/j.cnki.cjm.201406013InfluenceandcurativeefectofBifidobacteriumTetravaccineTabletsonserumendotoxinandprocalci
4、toninlevelsofpatientswithacutepancreatitisWANGWei-qiang,CHENHan—qing1.EmergencyDepartment;2.DigestiveDepartment,theSecondPeople’sHospitalofLinhai,Linhai317016.CinaCorrespondingauthor:WANGWei—qiang,Email:linhaiwangwq@126.eomAbstract:ObjectiveTodiscusstheinflu
5、enceandcurativeeffectofBifidobacteriumTetravaccineTabletsonser·amendotoxinandprocalcitonin(PCT)levelsofpatientswithacutepancreatitis(AP).Methods』66casesofpatientswithAPwereselectedanddividedintoobservationgroupandcontrolgroupatrandom.Bothgroupsweregivenconve
6、ntionaltreatmentincludingfastingandwater—deprivation,continuousgastrointestinaldecompression,in—feetionprevention,acidsuppression,antispasmodicandanalgesic,inhibitionofpancreaticsecretion,correctingwaterelectrolyteandacid—basedisordersetc.Thepatientsinobserv
7、ationgroupwereadditionallygiven1.5gBifidobacteriumTetravaccineTablets,perfusedthroughstomachtubeafterhydration,pinchedfor2houm,threetimesaday.ThechangesofserumendotoxinandPCTlevelsofpatientsinbothgroupswereobserved,andtheclinicalcurativeeffectwascompared.Res
8、ultsAfter7days’medicaltreatment,theserumendotoxinandPCTlevelsofpatientsinbothgroupsdeclinedtosomeextents(P<0.05orP<0.01),andthedecliningrateinobser—vationgroupwasmuchhigherthanthatincontrolgroup
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