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时间:2020-05-02
《hs-CRP和IL-6动态变化与脑动脉狭窄支架成形术后再狭窄的相关性研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、重庆医学2014年9月第43卷第27期3567论著·临床研究doi:10.3969/j.issn.1671—8348.2014.27.006hs—CRP和IL一6动态变化与脑动脉狭窄支架成形术后再狭窄的相关性研究温昌明,王新凯,张保朝(1.河南省南阳市中心医院神经内科473000;2.解放军71669部队医院内科,河南南阳473000)摘要:目的探讨血清超敏c反应蛋白(hs—cRP)和IL一6的动态变化与脑动脉狭窄支架成形术后再狭窄的相关性。方法回顾分析2011年3月至2O13年3月在河南省南阳市中心医院行脑动脉狭窄支架成形术的患者65例,观察其术前、术后不同时间点hs—CRP和I
2、L一6水平变化,并分析其与血管再狭窄的相关性。结果(1)脑动脉狭窄程度与患者血清hs—CRP和IL-6水平呈正相关(P<0.05)。(2)术后各时间点患者hs—CRP和IL-6水平明显升高,并于术后12h达到最高值后逐渐下降,而且再狭窄患者手术7d后hs—CRP和IL一6水平均显著高于无再狭窄患者,差异均有统计学意义(P0.05);有无再狭窄患者之间△hs—CRP和△IL一6比较差异均有统计学意义(P3、成形术后脑动脉再狭窄的过程中起着重要作用,监测血清hs—CRP和IL一6的动态变化对评估血管再狭窄具有一定价值。‘关键词:白细胞介素-6;超敏C反应蛋白;动脉狭窄;支架成形术;再狭窄中图分类号:R743.9文献标识码:A文章编号:1671—8348(2014)27—3567—03Studyofrelationshipbetweenlevelsofhs-CRPandIL‘6withrestenosisafterstentangioplastyincerebralarterialstenosisWenChangming,WangXinkai,ZhangBaochao(1.Departm4、entofNeurology,NanyangMunicipalCentralHospital,Nanyang,Henan473000,China;2.DepartmentofInternalMedicine,HospitalofPLATroop71669,Nanyang,Henan473000,China)Abstract:ObjectiveToinvestigatetherelationshipbetweenthedynamicchangesofhs—CRPandIL-6withrestenosisafterstentangioplastyincerebralarterialst5、enosis.Methods65patientswithcerebralarterystenosisstentangioplastyinNanyangMu—nicipalCentralHospitalfromMarch2011toMarch2013wereretrospective1yanalyzed.Thechangesofhs—CRPandIL-6levelsbe—foreoperationandatdifferentpostoperativetimepointswereobservedandtheircorrelationwithvascularrestenosiswasan6、lyzed.Results(1)Thecerebralarterystenosisdegreeandserumhs—CRPandIL一6levelswerepositivelycorrelated(P%0.05).(2)Corn—paringthehs—CRPandIL-6levelsatdifferenttimepointsshowedthatthepostoperativehs—CRPandIL-6levelsweresignificantlyincreased,reachedthehighestatpostoperative12handthengraduallydecline7、d.Thehs—CRPandIL一6levelsonpostoperative7dinthepatientswithrestenosisweresignificantlyhigherthanthoseinthepatientswithoutrestenosis(P~0.05).(3)Thehs—CRPandIL—6levelsatpostoperative6monthsinthepatientswithoutrestenosisweresignificantlydec
3、成形术后脑动脉再狭窄的过程中起着重要作用,监测血清hs—CRP和IL一6的动态变化对评估血管再狭窄具有一定价值。‘关键词:白细胞介素-6;超敏C反应蛋白;动脉狭窄;支架成形术;再狭窄中图分类号:R743.9文献标识码:A文章编号:1671—8348(2014)27—3567—03Studyofrelationshipbetweenlevelsofhs-CRPandIL‘6withrestenosisafterstentangioplastyincerebralarterialstenosisWenChangming,WangXinkai,ZhangBaochao(1.Departm
4、entofNeurology,NanyangMunicipalCentralHospital,Nanyang,Henan473000,China;2.DepartmentofInternalMedicine,HospitalofPLATroop71669,Nanyang,Henan473000,China)Abstract:ObjectiveToinvestigatetherelationshipbetweenthedynamicchangesofhs—CRPandIL-6withrestenosisafterstentangioplastyincerebralarterialst
5、enosis.Methods65patientswithcerebralarterystenosisstentangioplastyinNanyangMu—nicipalCentralHospitalfromMarch2011toMarch2013wereretrospective1yanalyzed.Thechangesofhs—CRPandIL-6levelsbe—foreoperationandatdifferentpostoperativetimepointswereobservedandtheircorrelationwithvascularrestenosiswasan
6、lyzed.Results(1)Thecerebralarterystenosisdegreeandserumhs—CRPandIL一6levelswerepositivelycorrelated(P%0.05).(2)Corn—paringthehs—CRPandIL-6levelsatdifferenttimepointsshowedthatthepostoperativehs—CRPandIL-6levelsweresignificantlyincreased,reachedthehighestatpostoperative12handthengraduallydecline
7、d.Thehs—CRPandIL一6levelsonpostoperative7dinthepatientswithrestenosisweresignificantlyhigherthanthoseinthepatientswithoutrestenosis(P~0.05).(3)Thehs—CRPandIL—6levelsatpostoperative6monthsinthepatientswithoutrestenosisweresignificantlydec
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