欢迎来到天天文库
浏览记录
ID:54589126
大小:291.22 KB
页数:3页
时间:2020-05-02
《原发性胃淋巴瘤58例临床诊治及其预后影响因素分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、海南医学2014年7月第25卷第13期]~ainanMedJrJuly2014,Vo1.25,No.13doi:10.3969~.issn.100376350.2014.13.0740·论著·原发性胃淋巴瘤58例临床诊治及其预后影响因素分析林煜光,李曦,吴子刚(北京大学深圳医院消化内科,广东深圳518036)【摘要】目的探讨原发性胃淋巴瘤(PGL)的临床特征和影响预后的相关因素。方法回顾性分析我院58例原发性胃淋巴瘤患者的临床、胃镜、病理及随访资料,采用单因素和多因素方法分析影响预后的相关因素。结果本组患者胃镜下肿瘤好发于胃窦及胃体,黏膜相关淋巴组织淋巴瘤(MALToma)和弥漫大B细胞淋巴
2、瘤(DLBCL)是主要病理类型,1、3、5年累积生存率分别为86.5%、76.1%和69.8%。单因素分析显示血清乳酸脱氢酶水平(LDH)、B症状、病理类型及临床分期是影响预后的相关因素(P3、eatmentandprognosisof58easesofprimarygastriclymphoma.LINYu-guang,LIxWUZi-gang.DepartmentofGastroenterology,ShenzhenHospitalofPekingUnwe~ity,Shenzhen518o3~Guangdong,CHINA【Abstract】ObjectiveToanalyzetheclinicalcharacteristicsandprognosisofprimarygastriclymphoma(PGL).MethodsWeretrospectivelyanalyzedth4、eclinicalandendoscopiccharacteristics,pathologyandfollow-updataof58PGLcases,andtriedtodefinepossiblefactorsthatinfluencetheprognosisbyunivariateandmultivariate.analysis.ResultsPrimarygastriclymphomamostlyOccurredingastricantrumandgastricboay.MALTlymphomaandDLBCLwerethemostcommonpathologicalsubtypes5、.Overallcumulativesurvivalsof1,3and5yearswere86.5%,76.1%and69.8%respectively.TheunivariateanalysisshowedthatLDHlevel,Bsymptoms,pathologicaltypesandclinicalstageswereprognosticfactors(P<0.05).MultivariateanalysisindicatedthatBsymptoms,pathologi—ealtypesandclinicalstageswereindependentprognosticfacto6、rsfP<0.05).ConclusionTheclinicalcharacteristicsofPGLwerenon-specific.Bsymptoms,pathologicaltypesandclinicalstageswereindependentprognosticfactors,whichwashelpfultomaketreatmentsandevaluateprognosis.【Keywords】Primarygastriclymphoma;Helicobacterpylori;Clinicalpathology;Prognosis;Influencefactor原发性胃淋巴7、瘤(Primarygastriclymphoma,PGL)Dawson关于原发性胃淋巴瘤的诊断标准[21。临床分发病率很低,约占胃恶性肿瘤的2%~8%1,其临床和内期采用改良的An—nArbor分期系统:I期(IE)肿瘤仅限镜下的表现无特异性,极易误诊,预后较胃癌要好,但有于胃壁;Ⅱ期(ⅡE)除胃肿瘤外,腹腔淋巴结受累;llI关影响原发性胃淋巴瘤长期生存的预后分析国内研期(ⅢE)除胃内肿瘤外,横膈两侧淋巴结受
3、eatmentandprognosisof58easesofprimarygastriclymphoma.LINYu-guang,LIxWUZi-gang.DepartmentofGastroenterology,ShenzhenHospitalofPekingUnwe~ity,Shenzhen518o3~Guangdong,CHINA【Abstract】ObjectiveToanalyzetheclinicalcharacteristicsandprognosisofprimarygastriclymphoma(PGL).MethodsWeretrospectivelyanalyzedth
4、eclinicalandendoscopiccharacteristics,pathologyandfollow-updataof58PGLcases,andtriedtodefinepossiblefactorsthatinfluencetheprognosisbyunivariateandmultivariate.analysis.ResultsPrimarygastriclymphomamostlyOccurredingastricantrumandgastricboay.MALTlymphomaandDLBCLwerethemostcommonpathologicalsubtypes
5、.Overallcumulativesurvivalsof1,3and5yearswere86.5%,76.1%and69.8%respectively.TheunivariateanalysisshowedthatLDHlevel,Bsymptoms,pathologicaltypesandclinicalstageswereprognosticfactors(P<0.05).MultivariateanalysisindicatedthatBsymptoms,pathologi—ealtypesandclinicalstageswereindependentprognosticfacto
6、rsfP<0.05).ConclusionTheclinicalcharacteristicsofPGLwerenon-specific.Bsymptoms,pathologicaltypesandclinicalstageswereindependentprognosticfactors,whichwashelpfultomaketreatmentsandevaluateprognosis.【Keywords】Primarygastriclymphoma;Helicobacterpylori;Clinicalpathology;Prognosis;Influencefactor原发性胃淋巴
7、瘤(Primarygastriclymphoma,PGL)Dawson关于原发性胃淋巴瘤的诊断标准[21。临床分发病率很低,约占胃恶性肿瘤的2%~8%1,其临床和内期采用改良的An—nArbor分期系统:I期(IE)肿瘤仅限镜下的表现无特异性,极易误诊,预后较胃癌要好,但有于胃壁;Ⅱ期(ⅡE)除胃肿瘤外,腹腔淋巴结受累;llI关影响原发性胃淋巴瘤长期生存的预后分析国内研期(ⅢE)除胃内肿瘤外,横膈两侧淋巴结受
此文档下载收益归作者所有