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时间:2020-05-02
《乳腺超声造影、彩色多普勒超声及磁共振灌注成像在评估乳腺癌新辅助化疗疗效中的对比研究.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第43卷第4期第449页华中科技大学学报(医学版)Vo1.43NO.4P.4492014年8月ActaMedUnivSciTechnolHuazhongAug.2014乳腺超声造影、彩色多普勒超声及磁共振灌注成像在评估乳腺癌新辅助化疗疗效中的对比研究张林,郝洁,王立平,沈文状,王单,杨亚龙华中科技大学同济医学院附属同济医院乳腺甲状腺外科超声影像科,武汉430030摘要:目的探讨超声造影技术在乳腺癌新辅助化疗疗效评估中的应用价值,对比其和彩色多普勒超声(彩超)及磁共振灌注成像在疗效评价中的表现。方法收集2011年11
2、月至2013年3月于华中科技大学同济医学院附属同济医院行新辅助化疗并手术治疗的乳腺癌病例27例。分别于第1次化疗前及手术前行乳腺彩色多普勒超声及超声造影检查,同时对其中13例患者于第1次化疗前及手术前行乳腺磁共振灌注成像检查。结果以术后病理反应分级为基准,彩超对新辅助化疗疗效评价的准确性低于超声造影检查。超声造影与磁共振灌注成像在评价疗效方面各有优势。超声造影所测癌灶直径较彩超大,治疗后能通过时间一强度曲线反映血流灌注水平的降低,其中峰值强度和曲线下面积的减少两组差异有统计学意义(P3、超声造影技术对乳腺癌新辅助化疗疗效的评估效果优于彩超,和磁共振灌注成像相比各有优势。超声造影能体现新辅助化疗的效果,其参数可能对疗效的预测有一定价值。关键词:乳腺肿瘤;新辅助化疗;超声造影;磁共振灌注成像中图分类号:R737.9DOI:10.3870/j.issn.1672—0741.2014.04.019Contrast—enhancedUltrasound,ColorDopplerUltrasoundandMRI—PWIforEvaluatingtheResponseofBreastCancertoNeoadj4、uvantChemotherapyZhangLin,HaoJie,WangLiping。etalDepartmentofBreastandThyroidSurgery,DepartmentofUltrasound,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,ChinaAbstractObjectiveToinvestigatetheapplicationvalueofcontrast5、enhancedultrasound(CEU)inassessingtheresponseofbreastcancertoneoadjuvantchemotherapy(NAC)andtocompareCEUwithcolordopplerultrasoundandmagneticreso—nanceperfusion-weightedimaging(MRI-PWI)intheevaluationoftreatmentefficacy.MethodsThisstudyincluded27breastcancerpa6、tientswhoreceivedNACandsurgicaltreatmentbetweenNovember201landMarch2013inTongJiHospita1。Wuhan。China.TheyallunderwentcolordopplerultrasoundandCEUbeforeandafterNAC.Amongthem.thirteenpatientsweresubjec—tedtoMRI—PWI.ResultsIntermsofthepathologicresponsegrade.CEUha7、dbetterperformanceinevaluatingtheresponseofNACthancolordopplerultrasound.CEUandMRI—PWIhadtheirownadvantagesinevaluationoftreatmentefficacy.ThetumorsizemeasuredbyCEUwaslargerthanbycolordopplerultrasound.AfterNAC,thereductionoftumor’Sbloodperfusioncouldbereflect8、edOnthetime-intensityeurve.Therewassignifciantdifferenceinthedecreaseofthepeakintensity(PI)andareaundercurve(AUC)betweenCEUandcolordopplerultrasound(P
3、超声造影技术对乳腺癌新辅助化疗疗效的评估效果优于彩超,和磁共振灌注成像相比各有优势。超声造影能体现新辅助化疗的效果,其参数可能对疗效的预测有一定价值。关键词:乳腺肿瘤;新辅助化疗;超声造影;磁共振灌注成像中图分类号:R737.9DOI:10.3870/j.issn.1672—0741.2014.04.019Contrast—enhancedUltrasound,ColorDopplerUltrasoundandMRI—PWIforEvaluatingtheResponseofBreastCancertoNeoadj
4、uvantChemotherapyZhangLin,HaoJie,WangLiping。etalDepartmentofBreastandThyroidSurgery,DepartmentofUltrasound,TongjiHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan430030,ChinaAbstractObjectiveToinvestigatetheapplicationvalueofcontrast
5、enhancedultrasound(CEU)inassessingtheresponseofbreastcancertoneoadjuvantchemotherapy(NAC)andtocompareCEUwithcolordopplerultrasoundandmagneticreso—nanceperfusion-weightedimaging(MRI-PWI)intheevaluationoftreatmentefficacy.MethodsThisstudyincluded27breastcancerpa
6、tientswhoreceivedNACandsurgicaltreatmentbetweenNovember201landMarch2013inTongJiHospita1。Wuhan。China.TheyallunderwentcolordopplerultrasoundandCEUbeforeandafterNAC.Amongthem.thirteenpatientsweresubjec—tedtoMRI—PWI.ResultsIntermsofthepathologicresponsegrade.CEUha
7、dbetterperformanceinevaluatingtheresponseofNACthancolordopplerultrasound.CEUandMRI—PWIhadtheirownadvantagesinevaluationoftreatmentefficacy.ThetumorsizemeasuredbyCEUwaslargerthanbycolordopplerultrasound.AfterNAC,thereductionoftumor’Sbloodperfusioncouldbereflect
8、edOnthetime-intensityeurve.Therewassignifciantdifferenceinthedecreaseofthepeakintensity(PI)andareaundercurve(AUC)betweenCEUandcolordopplerultrasound(P
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