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时间:2020-05-01
《冻融胚胎移植异位妊娠低发生率的原因分析.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、生殖医学杂志2014年3月第23卷第3期·233·DOI:10.3969/j.issn.1004—3845.2014.03.015冻融胚胎移植异位妊娠低发生率的原因分析柯雪,孙林,王磊,邵小光(辽宁省大连市妇女儿童医疗中心生殖医学科,大连116021)【摘要】目的比较新鲜胚胎移植或解冻胚胎移植妇女异位妊娠的发生情况,及冻融胚胎移植周期中不同内膜准备方案异位妊娠发生情况,分析其相关影响因素。方法对2006年1月至2013年5月于本生殖医学中心行体外受精/卵胞浆内单精子注射(IVF/ICSI)一胚胎移植术后的患者进行回顾性分析,包括3,073个新鲜移植周期(A组)、2,090个解冻移植周期(
2、B组),其中卵裂期胚胎移植1,997个周期(B1组),囊胚移植93个周期(B2组)。比较A组与B1组、A组与B2组异位妊娠发生率;比较自然周期法、激素替代周期法和促排卵周期三种内膜准备方案异位妊娠发生率;多元logistic回归分析异位妊娠相关因素。结果3,073个新鲜移植周期(A组)中,临床妊娠1,226周期,异位妊娠45周期,异位妊娠发生率为3.67(45/1,226);2,090个解冻周期中,临床妊娠893周期(B1组855周期,B2组38周期),B1组异位妊娠发生率1.17(1O/855),B2组异位妊娠发生率2.63(1/38),两组异位妊娠发生率均低于新鲜胚胎移植,有显著性差
3、异(P4、uteofDalianMateral&ChildMedicalHospita1.Dalianl16021[Abstract]objective:Tocomparetheincidenceofectopicpregnancy(EP)betweenfreshandfrozen—thawed(FET)embryotransfers,andexplorethegenerantcauseofEPamongdifferentendometrialpreparationprotocols.Methods:Thedataof3,073freshcyclesingroupAand2,090FETcycle5、singroupBincluding1,997cleavage—stageingroupB1and93blastocysttransfersingroupB2fromJan.2006toMay.2013wereanalyzedretrospectively.Theincidencesofectopicpregnancywerecomparedamongthreeendometrialpreparationprotocolsincludingnaturalcycle,hormonereplacementcycleandstimulatingovulationcycle.Theriskfac6、torsofEPwereidentifiedwithmultivariatelogisticregression.Results:Theincidenceofectopicpregnancywas3.67in3,073freshcycles.In2,090FETcycles,bothgroupB1(1.17)andgroupB2(2.63)hadsignificantlylowerEPratethanfreshcycles(P%0.05).Comparedwiththeotherendometrialpreparationgroups,EPrateinthenaturalcyclewas7、thesmallestwithstatisticallysignificance.TheectopicpregnancyratewasincreasedinthepatientswithoviductfactorsorhighsexhormonesontheembryotransferdXy.Conclusions:TheincidenceofEPinFETcycleswaslowerthanthatfreshembryotrans
4、uteofDalianMateral&ChildMedicalHospita1.Dalianl16021[Abstract]objective:Tocomparetheincidenceofectopicpregnancy(EP)betweenfreshandfrozen—thawed(FET)embryotransfers,andexplorethegenerantcauseofEPamongdifferentendometrialpreparationprotocols.Methods:Thedataof3,073freshcyclesingroupAand2,090FETcycle
5、singroupBincluding1,997cleavage—stageingroupB1and93blastocysttransfersingroupB2fromJan.2006toMay.2013wereanalyzedretrospectively.Theincidencesofectopicpregnancywerecomparedamongthreeendometrialpreparationprotocolsincludingnaturalcycle,hormonereplacementcycleandstimulatingovulationcycle.Theriskfac
6、torsofEPwereidentifiedwithmultivariatelogisticregression.Results:Theincidenceofectopicpregnancywas3.67in3,073freshcycles.In2,090FETcycles,bothgroupB1(1.17)andgroupB2(2.63)hadsignificantlylowerEPratethanfreshcycles(P%0.05).Comparedwiththeotherendometrialpreparationgroups,EPrateinthenaturalcyclewas
7、thesmallestwithstatisticallysignificance.TheectopicpregnancyratewasincreasedinthepatientswithoviductfactorsorhighsexhormonesontheembryotransferdXy.Conclusions:TheincidenceofEPinFETcycleswaslowerthanthatfreshembryotrans
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