欢迎来到天天文库
浏览记录
ID:54373133
大小:238.61 KB
页数:3页
时间:2020-05-01
《T单核苷酸多态性与代谢综合征的相关性.pdf》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、宁夏医学杂志2014年9月第36卷第9期NingxiaMedJ,Sep.2014,Vol36,No.9·781·Doi:10.13621/j.1001—5949.2014.09.0781著·宁夏回汉族人群脂联素基因SNP+276G/T单核苷酸多态性与代谢综合征的相关性武海亮‘,沈佳,陈芳。,刘雅娟,杨锐英[摘要]目的探讨宁夏回、汉族人群脂联素基因SNP+276G/T单核苷酸多态性与代谢综合征(MS)的相关性。方法收集回、汉族MS患者(MS组)207例和136例以及回、汉族健康体检者(对照组)98例和102例,采用PCR—
2、RFLP技术检测SNP+276G/T单核苷酸多态性,用ELISA法检测血清脂联素的浓度。结果汉族MS组GG基因型频率及G等位基因频率均高于汉族对照组(P<0.05),回汉族2组间基因型频率及等位基因频率差异均无统计学意义(P>0.05)。回、汉族MS组血清脂联素水平均低于其对照组(P<0.05),回、汉族TG+1TI’基因型血清脂联素水平低于GG基因型者。Logistic回归分析显示SNP+276基因多态性是汉族MS的危险因素。结论脂联素基因SNP+276G/T多态性可能与宁夏汉族MS相关,与宁夏回族MS无相关性。[关键
3、词]代谢综合征;脂联素;基因多态性;宁夏[中图分类号】R394[文献标识码】ARelationshipsbetweenadiponectingene+276nucleotideT/GpolymorphismwithmetabolicsyndromeinHuiandHannationalitiesinNingxiaWUHailiang,SHEN,CHENFang,LIUYajuan。,YANGRuiying.1.DepartmentofGerontology,GeneralHospitalofNingxiaMedicalU
4、niversity,Yinchuan750004,China;2.ICU,CardiovascularandCerebrovascularDiseasesHospitalofGeneralHo~italofNingxiaMedicalUniversity,Yinchuan750002,China;3.DepartmentofCardiology,YinchuanFirstPeople~Hospital,Yinchuan750001,ChinaCorrespondingauthor:YANGRuiying,Email:an
5、gelwhl@163.com[Abstract]ObjectiveToinvestigatetherelationshipbetweenadiponectin(APN)gene+276nueleotideG/Tpolymorphismwithmetabolicsyndrome(MS)inHuiandHannationalitiesinNingxia.MethodsThestudywasperformedin207Huipatientsand136HanpatientswithMS(MSgroup)andwasperfor
6、medin98Huihealthypeopleand102Harthealthypeople(controlgroup).PCR—RFLPandELISAwereusedtodetectthegenepolymorphismofAPNandtheserumAPNleve1.ResultsThefrequenciesofGGgeno—typeandGalleleinHanMSgroupwerehigherthanthoseinHancontrolgroup(P<0.05).Thefrequenciesofgenotypea
7、ndallelewerenotsignificantlydifferentbetweenHuiMSgroupandHuicontrolgroup(P>0.05).Comparedwiththecontmlgroup,theserumAPNlevelinMSgroupwaslowerinbothHuiandHannationalities(P<0。05).TheserumAPNlevelinsubjectwithTG+TTgenotypeswasandHannationality(P<0.05).Logisticregre
8、ssionanalysisshowedthatAPN+276G/TgenepolymorphismsweretheriskfactorsformetabolicsyndromeinHansubjects.Conclusion+276G/TpolymorphismofAPNmightbeassociatedwithMS
此文档下载收益归作者所有