Ⅱ型糖尿病患者认知功能障碍危险因素分析.pdf

《Ⅱ型糖尿病患者认知功能障碍危险因素分析.pdf》由会员上传分享，免费在线阅读，更多相关内容在应用文档-天天文库。

1、第30卷第4期哈尔滨商业大学学报(自然科学版)v。1．30N。．42014年8月JournalofHarbinUniversi1yofCommerce(NaturalSciencesEdition)Aug．2014Ⅱ型糖尿病患者认知功能障碍危险因素分析王凯亮，张军，韩呖，李洪梅(北京市煤炭总医院内分泌科，北京100028)摘要：探讨Ⅱ型糖尿病患者轻度认知功能障碍(MCI)的相关危险因素．将165例Ⅱ型糖尿病患者根据MoCA北京版量表分为Ⅱ型糖尿病认知功能障碍组95例及Ⅱ型糖尿病认知功能正常组7O例．比较两组的临床资料，进行非条件Logistic回归分析认知功能障碍的相关危险因素．

2、与对照组比较，MCI组较对照组糖尿病病程长(P<0．05)，Hb／Ic、空腹胰岛素水平、TC、LDL—C水平、同型半胱氨酸水平、尿微量白蛋白明显高于对照组(P<0．05)；两组间BMI、空腹血糖、餐后2h血糖、TG、HDL—C、肌酐、血尿酸、收缩压、舒张压间差异无统计学意义．非条件Logistic回归分析结果显示高龄、血糖控制不佳、糖尿病病程长、高血压病史、糖尿病肾病、糖尿病周围神经病变均是Ⅱ型DM合并认知功能障碍的独立危险因素．早期诊断有助于预防和减少认知功能障碍的发生．关键词：11型糖尿病；认知功能障碍中图分类号：R285文献标识码文章编号：1672—0946(2014)04

3、—0405—04Studyoncognitivedysfunctionandanalysisofriskfactorofpatientswithtype—-lIdiabetesmellitusWANGKai—liang，ZHANGJun，HANYang，LIHong—met(BranchofEndocrinology，BeijingGeneralHospitalofCoal，Beijing100028，China)Abstract：Toinvestigatetheriskfactorsofmildcognitiveimpairment(MCI)inpatientswithtype

4、IIdiabetes(T2DM)，atotalof165T2DMpatientsweredividedintoT2DMwithMCIgroup(n：95)andT2DMwithnormalcognitivefunction(NMCI)group(=70)．Montre-alcognitiveassessmentscale(MoCA)、Arasusedtoassessthefunctionalstatusintwogroupsofpatients．Nonconditionlogsticregressionwasusedtoanalyzetherelatedfactorsofcogn

5、i—tivedysfunction．Comparedwiththecontrolgroup，thediabetescourse，bloodlevelsofHbAIc，fastinginsulin，totalcholesterol，low—densitylipoprotein～cholesterol，homocysteicacid，andmicrourineproteinsignificanllyincreased．TherewerenosignificantdifferencesinBMI，fastingbloodglucose，postprandial2hbloodsugar，

6、triglycerides，highdensitylipo—protein—cholesterol，creatinine，blooduricacid，contractivepressure，anddiastolicbloodpressurebetweenthetwogroups．Muhipleregressionanalysisshowedthatolderage，ineffi—cientcontrolofbloodglucose，longdurstionofdiabetesmellitus，historyofhypertension，di—abeticnephropathy，a

7、nddiabeticperine。uropathyweresignificantlyindependentdeterminantf0rtheT2DMwithcognitivedysfunction．ManyriskfactorsmayplayapartinT2DMwithMCI．EarlydetectionandpromptingmedicalattentionmayhelppreventanddecreasetheprevalenceofMCIinpatientswithT2D