单侧与双侧顺行性脑灌注对认知能力的影响

《单侧与双侧顺行性脑灌注对认知能力的影响》由会员上传分享，免费在线阅读，更多相关内容在行业资料-天天文库。

1、·8·中国胸心血管外科临床杂志2005年2月第12卷第1期ChinJClinThoracrdi!!!曼：!!!!!!：!!：：2：·临床研究论著·单侧与双侧顺行性脑灌注对认知能力的影响田良鑫孙立忠程卫平杨九光郑军刘宁宁(中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院血管外科中心，北京100037)摘要：目的比较全主动脉弓置换术中应用单侧顺行性脑灌注和双侧顺行性脑灌注对认知能力的影响。方法16例全主动脉弓置换术患者按随机数字表法随机分为单侧顺行性脑灌注组和双侧顺行性脑灌注组，每组各8例。两组均行

2、术前、术后神经系统物理检查、颅脑计算机体层摄影(CT)和认知能力测验比较。结果无手术及近期死亡，无新发脑梗塞出现。两组各有1例出现短暂性神经功能异常，两组间术前和术后的认知能力比较差别无统计学意义(P>O．05)。结论在基底动脉环完整、存在有效侧枝循环的条件下，单侧顺行性脑灌注及双侧顺行性脑灌注均能取得良好的效果，两种脑保护方法对认知能力的影响无统计学意义。关键词：脑血管循环；全主动脉弓置换术；单侧顺行性脑灌注；双侧顺行性脑灌注；神经心理学测验中图分类号：R654．1；R654．3文献标识码：A文章编号：1

3、007—4848(2005)01—0008—03ProspectiveRandomisedNeuroc0gnitiVeStudyofUnilateralandBilateralAntegradeSelectiveCerebralPerfusionforTotalAorticArchReplacement7’，AⅣLiangxin，SUNLi—zhong，CHENGWei—ping，YANGtliuguang，ZHENG．IunIIUNing—ning．(DepartmentofCardiac’Surgery

4、，Cardiovasc’ularInstituteandFuwaiHospital，ChineseAcademyofMedical5cl'eHceS8PekingUnionMedicalCollege，Beijing100037，P．R．China)Abstract：ObjectiveTocomparethecerebralprotectiveeffectofunilateralandbilateralantegradeselectivecerebralperfusionduringtotalaortica

5、rchreplacement，particularlywithrespecttOneuropsychologicaloutcome．MethodsFromJune2003tOMarch2004，16patientswhounderwenttotalaorticarchreplacementwererandomlyallocatedtooneoftwomethodsofbrainprotection：unilateralantegradeselectivecerebralperfusion(unilatera

6、lgroup，n一8)orbilateralantegradecerebralperfusion(bilateralgroup，n一8)．Preoperativeandpostoperativeneurologicalexamination，braincomputedtomography(CT)scan，andcognitivefunctiontestswereperformed．ResultsAllpatientssurvivedtheoperationsandweredischargedfromhosp

7、ita1．Nonewbraininfarctionoccurred．Transientneurologicdysfunctionoccurredin1patientofeachgroup．Therewerenointergroupdifferencesinthescoresofpreoperativeandpostoperativecognitivefunction(P>0．05)．ConclusionBothmethodsofbrainprotectionforpatientsundergoingtota

8、laorticarchreplacementresultinfavorableandsimilareffectofbrainprotectionintermofcognitivefunctionprovidedthecircleofWillisispatentandcollateralflowisadequate．Keywords：Cerebrovascularcirculation；Totalaorticarc