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1、®世界华人消化杂志2011年7月18日;19(20):2104-2108wcjd@wjgnet.comISSN1009-3079(print)ISSN2219-2859(online)基础研究BASICRESEARCHENT1在人肝癌细胞中的表达特征及临床意义蒋星星,傅华群,巢映辉,刘征宇■背景资料蒋星星,傅华群,巢映辉,南昌大学第二附属医院肝胆外科RESULTS:ENT1couldbedetectedonthemem-细胞膜核苷载体江西省南昌市330006braneofthethreehumanH
2、CCcelllines.The对核苷类化疗药刘征宇,南昌大学医学院实验教学部江西省南昌市330031蒋星星,2008级硕士研究生,主要从事肝胆外科基础与临床研expressionlevelsofENT1mRNAinHCCcell物的细胞内外转运起着至关重要究.lineswerehigherthanthatinthebreastcancer江西省卫生厅中医药科研基金资助项目,No.2009021的作用,细胞膜核cellline(HuH-7:0.756±0.019;HepG2:0.469±作者贡献分布:
3、此课题由傅华群与蒋星星设计;刘征宇为项目负苷载体的表达水责人,指导实验;数据分析由巢映辉完成;本文撰写由蒋星星与0.041;Hep3B:0.580±0.030;MCF-7:0.356±0.029).平,直接决定了细傅华群完成.TheexpressionlevelofENT1mRNAdiffered胞内核苷类药物通讯作者:刘征宇,330031,江西省南昌市,南昌大学医学院实的浓度,从而影响验教学部.yunyucnc@sina.comsignificantlyamongthethreehumanHCCc
4、ell肿瘤的化疗效果.收稿日期:2011-05-07修回日期:2011-06-21lines.TreatmentwithroscovitineincreasedtheENT1对核苷类化接受日期:2011-06-28在线出版日期:2011-07-18expressionlevelofENT1mRNA(0.737±0.017疗药的转运作用vs0.345±0.027,P<0.05).最为突出.ExpressioncharacteristicsofCONCLUSION:ENT1waslocalizedtot
5、heENT1inhumanhepatocellularmembraneofHCCcells.TheexpressionlevelscarcinomacellsofENT1mRNAvaryamongdifferentHCCcelllines.TreatmentwithroscovitineincreasedtheXing-XingJiang,Hua-QunFu,Ying-HuiChao,expressionlevelofENT1mRNAinHCCcellZheng-YuLiulines.Xing-Xi
6、ngJiang,Hua-QunFu,Ying-HuiChao,Depart-KeyWords:Nucleosidetransporters;HepatocellularmentofHepatobiliarySurgery,theSecondAffiliatedHos-carcinomacells;Equilibrativenucleosidetransporter1pitalofNanchangUniversity,Nanchang330006,JiangxiProvince,ChinaZheng-
7、YuLiu,DepartmentofExperimentalTeaching,JiangXX,FuHQ,ChaoYH,LiuZY.Expressioncharacter-MedicalCollegeofNanchangUniversity,NanchangisticsofENT1inhumanhepatocellularcarcinomacells.330031,JiangxiProvince,ChinaShijieHuarenXiaohuaZazhi2011;19(20):2104-2108Sup
8、portedby:theChineseMedicineResearchFoundationoftheHealthBureauofJiangxiProvince,No.2009021Correspondenceto:Zheng-YuLiu,DepartmentofExperi-mentalTeaching,MedicalCollegeofNanchangUniversity,摘要Nanchang330031,JiangxiProvince,目的:探讨ENT1在人肝癌细胞
