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1、InternationalJournalofFoodMicrobiology103(2005)143–155www.elsevier.com/locate/ijfoodmicroProbioticeffectsofLactobacilluscaseionDSS-inducedulcerativecolitisinmiceM.V.Herı´asa,T,1,J.F.J.G.Koninkxb,J.G.Vosb,c,J.H.J.Huisin’tVelda,d,F,J.E.vanDijkbaDepartment
2、ofPublicHealthandFoodSafety,FacultyofVeterinaryMedicine,UtrechtUniversity,Yalelaan2,3584CMUtrecht,TheNetherlandsbDepartmentofPathobiology,Yalelaan1,3584CLUtrecht,FacultyofVeterinaryMedicine,UtrechtUniversity,TheNetherlandscLaboratoryforToxicology,Pathol
3、ogyandGenetics,NationalInstituteofPublicHealthandtheEnvironment,AntonievanLeeuwenhoeklaan9,3720BABilthoven,TheNetherlandsdYakultNederlandB.V.,Prof.J.H.Bavincklaan5,1183ATAmstelveen,TheNetherlandsReceived20February2004;receivedinrevisedform30August2004;a
4、ccepted26November2004AbstractWetestedtheeffectofLactobacilluscaseistrainShirota(LcS)onthemurinemodelofulcerativecolitisinducedbydextransodiumsulphate.TheeffectofLcSwastestedeitherasaprophylactic10daysbeforetheonsetofthedisease,simultaneouslywithulcerati
5、vecolitisinductionorcontinued10daysafterthediseasewasinduced.LcSwasnotabletopreventthediseaseinductioninanyoftheexperiments.However,importantclinicalparametersincludingbloodanemiaindicators,bodyweight,andorganweightwereimprovedintheanimalsreceivingLcSas
6、comparedwiththeulcerativecolitis-inducedcontrols.IncreasedcolonicepithelialregenerationintheLcStreatedanimalswasobservedinthechronicstage.TheresultsseemedbetterforthesimultaneousshortLcStreatmentwheresomeparametersremainedsimilartothePBScontrols,includi
7、ngdiseaseactivityscoresmeasuredintheacutestage.WecanconcludethatalthoughLcSalonecannotpreventtheinductionofulcerativecolitisbydextransodiumsulphate,itcanimprovetheclinicalconditionofthemice.Thiscouldimplyimportantbiologicalconsequencesforthehumansituati
8、on.FurtherstudiesincludingLcSorotherprobioticbacteriatogetherwiththeavailabletreatmentareencouraged.D2005ElsevierB.V.Allrightsreserved.Keywords:LactobacilluscaseistrainShirota;Dextransodiumsulphate-inducedulcerativecolitis;Mice;P
