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时间:2020-04-27
《使用VSD治疗的开放外伤患者血清中炎症因子水平变化及相关性研究-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、第32卷第2期石河子大学学报(自然科学版)Vo1.32No.22014年4月JournalofShiheziUniversity(NaturalScience)Apr.2014文章编号:1007—7383(2014)02—0208-05使用VSD治疗的开放外伤患者血清中炎症因子水平变化及相关性研究陈磊,王维山,阮智,董金波,史晨辉(石河子大学医学院第一附属医院骨一科,石河子832008)摘要:为探讨开放外伤患者在使用VSD治疗后,血清中炎症因子:肿瘤坏死因子c~(TNF—d)、白介素一6(IL一6)、白介素一
2、8(IL一8)、白介素一IO(IL一10)的变化及影响。采用随机选取2013年1月~2013年10月在我院骨科住院的开放外伤患者,60例使用VSD治疗的患者为研究组.50例常规换药治疗的患者作为对照组。分别于第一次治疗后第0.5、1、2、3、5、7天采集外周静脉血,用酶联免疫吸附法(ELISA)~定血清中TNF一、IL一6、IL-8、IL—l0的含量并对照研究。结果显示,治疗前研究组和对照组静脉血TNF一Ⅸ、IL一6、IL一8、IL一10含量无显著性差异(P>O.05);治疗后两组TNF一、IL一6、IL一8
3、、IL一10含量均开始升高。治疗后12h开始,研究组的外周静脉血TNF一0【含量较对照组明显降低,且具有统计学差异(P4、pheralBloodInflammatoryFactorsinOpenTraumaPatientsTreatedwithVSDCHENLei,WANGWeishan,RUANZhi,DONGJinbo,SHIChenhui(DepartmentofOrthopedics,theFirstAfiliatedHospital,SchoolofMedicine,ShiheziUniversity,Shihezi832002,China)Abstract:Toexplorethelevelofperipheralb5、loodTNF一0I.IL一6.IL一8andIL-IOinopentraumapatientstreatedwithVSD.110in-hospitalopentraumapatients,including60treatedwithVSDand50treatedwithconventionaldresschanging,wererandomlycollectedfromJanuarytoOctoberof2013.ThelevelofTNF—,IL一6,IL一8,IL一10inperipheralbloo6、dweredetectedbyELISAatthehalf,1st,2nd,3rd,5thand7thdayafterthefirsttreatment.ThelevelofTNF一0【,IL一6,IL一8andIL-10wasnosignificantdifferencebetweenthetwogroupsbeforetreatment(P>0.05).However,thelevelofTNF—Ot,IL一6,IL一8andIL一10,inbothgroups,wasincreasedafterthet7、reatments.TNF-ctinVSDgroupwaslowerthanthatinthecontrolat12haftertreatmentfP<0.05).IL-6,IL一8,IL-IOinVSDgroupwaslowerthanthatinthecontrolatthe1stdayaftertreatment(P<0.05).VSDtreatmentcaneliminatedinflammatoryfactorsofwoundmuchearlierthantheconventionalways,SO8、astoavoidtheinflammatoryresponseanddeterioration,whichisbeneficialtowoundhealing.Keywords:VSD;Opentrauma;Inflammatoryfactors收稿日期:2013—11-15基金项目:石河子大学医学院第一附属医院医疗技术应用项目(YL2012一R008)作者简介:陈磊(1981一),男,主治医师,
4、pheralBloodInflammatoryFactorsinOpenTraumaPatientsTreatedwithVSDCHENLei,WANGWeishan,RUANZhi,DONGJinbo,SHIChenhui(DepartmentofOrthopedics,theFirstAfiliatedHospital,SchoolofMedicine,ShiheziUniversity,Shihezi832002,China)Abstract:Toexplorethelevelofperipheralb
5、loodTNF一0I.IL一6.IL一8andIL-IOinopentraumapatientstreatedwithVSD.110in-hospitalopentraumapatients,including60treatedwithVSDand50treatedwithconventionaldresschanging,wererandomlycollectedfromJanuarytoOctoberof2013.ThelevelofTNF—,IL一6,IL一8,IL一10inperipheralbloo
6、dweredetectedbyELISAatthehalf,1st,2nd,3rd,5thand7thdayafterthefirsttreatment.ThelevelofTNF一0【,IL一6,IL一8andIL-10wasnosignificantdifferencebetweenthetwogroupsbeforetreatment(P>0.05).However,thelevelofTNF—Ot,IL一6,IL一8andIL一10,inbothgroups,wasincreasedafterthet
7、reatments.TNF-ctinVSDgroupwaslowerthanthatinthecontrolat12haftertreatmentfP<0.05).IL-6,IL一8,IL-IOinVSDgroupwaslowerthanthatinthecontrolatthe1stdayaftertreatment(P<0.05).VSDtreatmentcaneliminatedinflammatoryfactorsofwoundmuchearlierthantheconventionalways,SO
8、astoavoidtheinflammatoryresponseanddeterioration,whichisbeneficialtowoundhealing.Keywords:VSD;Opentrauma;Inflammatoryfactors收稿日期:2013—11-15基金项目:石河子大学医学院第一附属医院医疗技术应用项目(YL2012一R008)作者简介:陈磊(1981一),男,主治医师,
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