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时间:2020-04-27
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1、波谱学杂志第31卷第1期V0l_31No.12014年3月ChineseJournalofMagneticResonanceMar.2014Article:1000-4556(2014)01-020—12USPIOHighResolutionNeurovascularImaginginaRatStrokeModelofTransientMiddleCerebralArteryOcclusionSHENYi—rain,ZHENGWei—li,CHENGYu—chungN,DINGYu—chuan,HIGASHIDATetsuhiro,,Jie,YEYong—q
2、uan,RAYNAUDJeall—Sebastien,HAACKEEMark(1.DepartmentofRadiology,WayneStateUniversitySchoolofMedicine,Detroit48201,USA;2.DepartmentofNeurologicalSurgery,WayneStateUniversitySchoolofMedicine,Detroit48201,USA;3.GuerbetResearch,Aulnay-Sous-Bois93600,France;4.DepartmentofBiomedicalEngine
3、ering,WayneStateUniversity,Detroit48201,USA)Abstract:Angiogenesisinducingagents,suchasSildenafil,canbeusedtotreatstroke.Inthisstudy.USPIO—enhancedMRJwasusedtovisualizecollateralvesselsinthepenumbralareaoflesionsofratssubjectedtotransientmiddlecerebralarteryocclusion(tMCA01.andtheev
4、aluateeficacyoftheSildenafiltreatment.Here,P904,aUSPIOagent,wasusedasaT1reducingagentatalowdoseforMRangiographyandasaT2reducingagentatamoderatedoseforvisualizationofverysmallvesselsongradientechosusceptibility—weightedimaging(SWI).SWIscanswithout/withUSPIOinjectionwereperformedfort
5、hefollowingcases:tMCA0withoutanytreatment(月=5),tMCAOwithSildenafiltreatment(=6),andshamtMCAO(=1)atfourdifferenttimepoints(i.e.,baseline,24h,twoweeksandfourweeksaftertMCAO).Thepresenceofnewlydevelopedvesselsintheperipheryoftheischemiccorewasonlyobservedinthoseanimalsshowingsevereisc
6、hemicbraindamageandatthesametimereceivedSildenafiltreatmentattwoweeksposttMCAO.Thisworksuggeststhat,at7T,highresolutionSWIinconiunctionwithUSPIOinectionatamoderatedoseCarlbeusedtovisualizepost.strokeangiogenesisiflthetMCA0ratmode1.Keywords:MRI,stroke,angiogenesis,SWI,USPIO,neurovas
7、culatm'eCLCnumber:O482.53Documentcode:AReceiveddate:2013.10-16:Reviseddate:2013-11-12Foundationitem:HeartandStrokeFoundationofCanada(HSFC),SynchrotronMedicalImagingTeamGrant(CIF99472)Biography:SHENYi—min(1961一),male,bominJiangsu,PhD.,hisresearchfocusesonMRI,Te1.:+01—313-966—0579,fa
8、x:+01-313—745—9182.E—mail:
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