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1、治疗寻常座疮最佳(Thebesttreatmentforacneisacne)GeneralacneoverviewAcnevulgaris(acnevulgaris)isachronicinflammationofhairfolliclesandsebaceousglands・Itmainlyoccursinfattyareassuchasfaceandchest,whichhaveself-limitingandmulti-formskinlesions・Acne,papules,pustules,nodules,
2、oftenaccompaniedbysebumspillage・Afterpuberty,mostofthemarecuredorreduced・Inthepast,acnewasthoughttobeasebaceousdisease,whichineffectincludedhairfollicles,sebaceousglandsandepidermis.Itbelongstothecategoryof"lungwindacneinChinesemedicine・Theetiologyofacne(I)cause
3、ofdiseaseAcneisamultifactordisease,mainlytoproducemoresebum,hairfollicleepitheliumcornificationhyperfunctionandhairfollicleinpropionicacidacnebacillusproliferation,alsotohavecertaingeneticfactors,thedevelopmentofthesebaceousglandsandthesebaceousglandsproduceinde
4、pendentofandrogenandandrogenincreasedwithage,endocrine,geneticfactors,suchasthesebaceousglandsofacnepatientsislarger,thesebaceousglandssecretionproductismorethannormal,becauseofincreasedsecretionofsebaceousgland,sebumoleicacidlevelsdecreaserelatively,centralAsia
5、(negativecorrelation)bothaffectfatsynthesis,causefollicularepitheliumlackoffattyacids,thusinducingexcessivefolliclekeratinization,epithelialcellscannotnormalloss,leadingtoexcessivedecrescenthairfolliclemouth,skincan，texpel,sedimentationinthehairfollicle,theforma
6、tionofacne・Thenormalparasiticinthehairfollicleacneacnepropionicacidbacillus(PA),chaffsporebacteriumandtheepidermisstaphylococcus,whenthefreefattyacidsincreased,acnepropionicacidbacillusdoesnotproduceenoughenzymedecompositionleatherfat,cloggedfattyacidsmakeproduc
7、enonspecificinflaminationaroundhairfollicles,acnepropionicacidbacilluscanalsosecretelowmolecularpeptide,attractneutrophilsinthehairfollicle,causeitshydrolysisenzymerelease,makethehairfollicleepithelialseepageburst,leadtohairfolliclescontentsintosurroundingdermal
8、tissue,inflaminationcausedfromthesimpletothepimple,abscess,nodules,cysts,aseriesofclinicalmanifestations・Acneskinin5patientswithalphareductaseishigherthannormal,5alph
