vulgaris and acne related disorders痤疮和痤疮相关疾病（ppt47）课件

《vulgaris and acne related disorders痤疮和痤疮相关疾病（ppt47）课件》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。

1、AcnevulgarisandAcnerelateddisordersDr.MohammedA.Al-ShahwanM.D.CollegeofMedicineKingSaudUniversityObjectivesAcquiringknowledgeoftheetiologyandpathogenesisofacnevulgaris.Understandingthediseasespectrumofacnevulgaris.Acquiringknowledgeofthetherapeuticoptionsforacnevulgarisandtheirindic

2、ations.Tobefamiliarwiththeetiology,clinicaltypesandtreatmentofrosacea.AcnevulgarisIsachronicinflammatorydisorderofthepilosebaceousapparatusofcertainbodyareasresultingingreasinessandpolymorphicskineruption.IncidenceAcneaffectsallskintypes,themaleandfemaleratioisvirtuallythesamebutten

3、dstobemoresevereinmales.85%affectstheagegroup12–24years8%affectstheagegroup25–34years3%affectstheagegroup35–44yearsPathogenesis(threemainstepsrecognizedandhypothesized)1.FollicularHyperkeratosis(thecausenotfullyunderstood)theorysuggest:deficiencyinLinoleicacidtheeffectofAndrogen(DHT

4、)theeffectofInterleukin-1TheeffectofP.acnePerifollicularHyperkeratosishistology2.Abnormalproductionofsebumwhichcanincreasefurtherbytheresponseofsebaceousglandstotestosterone&DHT3.ColonizationoftheaffectedunitwithbacteriaPropionibacteriumacneandyeastnamedMalasseziafurfurPropionibacte

5、riumacneMalasseziafurfurPropionobacteriumacnelipasesactonsebaceousfattyacid(Triglycrides)toreleaseirritantfreefattyacidandlow-molecular-weightpeptideanextracellularfactorthatpenetratethefollicularwallandstimulatePolymorphsandLymphocytesinitiatinginflammationHydrolyticenzymesreleased

6、fromtheactivatedcomplementantibodiescomplextogetherwithexoenzymesproducedfromPacnecauseruptureoffollicularwallOncethewallisdamaged,Variousagents(prostaglandin-likesubstance,aminoacid,shortchainfattyacids)thatareproducedbytheinflammatorycellsandPacneextrudetothedermiscausingmoreinfl

7、ammationClinicalfeaturespolymorphicskineruptioncomposedof:PapulesComedones(Open“Blackheads”orclosed“Whiteheads”)InflammatorypapulesPustuleNoduleCystOpenComedones(Blackheads)OpenComedonesClosedComedones(Whitehead)ClosedComedonesInflammatorypapulesInflammatorypapulesPustulesPustulesNo

8、dulesNoduleCystsNeo