补肾活血法治疗肾虚型骨关节炎临床研究.doc

《补肾活血法治疗肾虚型骨关节炎临床研究.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、补肾活血法治疗肾虚型骨关节炎临床研究作者：刘毅，周青【摘耍】目的观察补肾活血方治疗肾虚型膝骨关节炎的临床疗效及对炎症因子的影响。方法选取滕骨关节炎患者113例，随机分为治疗组(5&例)和対照组(57例),分别采用补肾活血方和塞來昔布、氨基甸萄糖联合用药治疗，观察2纽临床疗效，应用平均Womac关节炎指数评分和平均骨关节炎严重程度指数评定用药前后临床症状改善情况採用ELISA法检测血淸炎症因子肿瘤坏死因子(TNF)"、白细胞介素(IL)6结果治疗纽•总有效率为89.3%,优于对照组(P<0.05)；Womac关节炎指数评分较治疗前显

2、著改善(P<O.Ol),与对照组比较有显著差异(P<0.05)；骨关节炎严重程度指数较治疗前显著改善(P&1UO.O5),与对照组尢显著差异(P>O.O5)。治疗纽血清TNF-a、IL-6水平明显降低(P<0.01,P<0.05)o结论补肾活血方治疗肾虚烈膝骨关节炎总体疗效优于塞来昔布、氨基葡萄糖联合用一药；通过抑制炎症因子的产生而减轻炎症反应是英重要机理之一。【关键词】补肾活血法；肾虚；骨关节炎Abstract：ObjectiveToexploretheclinicaleffiicacyandeffect

3、oncytokinesofinvigoratingthekidneyandactivatingbloodfomulaontreatingosteoarthritispatientsinthepatternofkidneydeficiency.Methods113patientswithkneeosteoarthritiswererandomlydividedintotwogroupsincluding56casesoftreatmentgroupand57casesofcontrolgroup,whichweretreatedbyinv

4、igoratingthekidneyandactivatingbloodlbmulaandcombinatonofCelecoxibandGlucosaminerespectively.TheclinicaleffiicacyoftwogroupswereinvestigatedbyWomacosteoarthritisindexandtheaverageseverityofOAindex・ThechangesofseruminflammatorycytokinesTNF-aandIL-6weredetectedbyELISA.Resu

5、ltsThetotalefficiencyofthetreatmentgroupwas89.3%andbetterthanthecontrolgroup(P<O・O5)after16weeksoftreatment.WomacosteoarthritisindexandOAseverityindexoftreatmentgroupwereimprovedsignificantlycomparedwithpre-treatment(P<0.01,P<0.05).Therewassignificantdifferencei

6、nWomacosteoarthritisindex(P<0.05)andnosignificantdifferenceinOAseverityindex(P>O.O5)comparedwithcontrolgroup.TheserumTNF-a,IL・6levelsoftreatmentgroupsignificantlydecreasedaftertreatmentintreatmentgroup(P<O.Ol,P<0.05).ConclusionTheinvigoratingthekidneyandactiv

7、atingbloodfomulahadbetterclinicaleffiicacyintreatingkneeosetoarthritisthancombinatontherapyofCelecoxibandGlucosamine・Inhibitionofcytokineproductionandreducingtheinflammatoryreactionareoneofthekeymechanisms.Keywords：invigoratingthekidneyandactivatingbloodtherapy；kidneydef

8、iciency；osteoarthitis骨关节炎(Osteoarthritis,OA)多见于老年人，发病率高，该病不仅可引起关节软骨损害,而且还累及软骨下骨、韧带、关节囊、滑膜和关节周围肌肉，最终导致关节