不同时期慢性HBV感染者血清IFN-λs水平的变化-论文.pdf

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1、新医学2014年2月第45卷第2期119临床研究论著不同时期慢性HBV感染者血清IFN—ks水平的变化杜以真王晓花张孝国张纵阚晓徐皖苏【摘要】目的了解不同时期慢性HBV感染者血清IFN—ks水平，探讨其变化与慢性HBV感染进程的关系。方法选择120例慢性HBV感染者，其中HBV携带者、慢性乙型病毒性肝炎(慢乙肝)患者、乙肝肝硬化患者、HBV相关肝癌患者各30例，以20名健康人为对照。采用双抗体夹心ELISA法，检测各组研究对象血清IFN—ks(IL一29、IL-28A和IL一28B)水平。结果慢乙肝、乙肝肝硬化、HBV相关肝癌患

2、者的血清IFN—hl(IL-29)水平均明显低于健康对照组(P均<0．O1)，慢乙肝、乙肝肝硬化、HBV相关肝癌患者血清IFN—kl(IL一29)水平明显低于HBV携带者(尸均<0．01)；HBV携带者血清IL一29水平与健康对照组相近(P>0．05)。各组慢性HBV感染患者的血清IFN—k2(IL一28A)水平与健康对照组比较均无统计学意义(P>0．05)。HBV相关肝癌患者血清IFN一3(IL-28B)水平高于健康人、HBV携带者、慢乙肝患者、乙肝肝硬化患者(P均<0．01)；HBV携带者、慢乙肝、乙肝肝硬化和健康对照组间血

3、清IL-28B水平比较差异无统计学意义(P>0．05)。结论慢性HBV感染者血清IFN—kl(IL-29)水平明显下降，而且HBV相关肝癌患者血清IFN—k3(IL一28B)的水平明显升高，可能与肝癌的发生有关。【关键词】血清Ⅲ型干扰素；慢性HBV感染；白细胞介素Seruminterferon-lambdaofdiferentstagesinpatientswithchronicHBVinfectionDUYi—zhen．WANGXiao—hua，ZHANGXiao—guo，ZHANGZo，KANXiao，XUWan—sJina

4、nInfectiousDiseaseAffiliatedttospi一￡0fofShandongUniversity．Ji~an250021，ChinaCorrespondingauthor，XUWan—SU，E—mail：xuwamudyz@163．corn【Abstract】ObjectiveTostudyIFN—kslevelsinpatientswithchronichepatitisBvirus(HBV)in—fections，andinvestigatetherelationshipbetweenhumantypeI

5、IIinterferons(IFN—ks)andchronicHBVinfec·tion．Methods120chronicHBVinfectionpatientswererecruited，anddividedinto4groups：chronicHBVcarriers，chronichepatitisBpatients，HBVrelatedcirrhosisandHBVrelatedhepatocellularcarcinomapa—tients．20healthypeoplewereasnegativecontrols．I

6、FN—kslevelsweredetectedbyEnzyme—linkedimmunosor—bentassay(ELISA)．ResultsLevelsofIFN-kl(IL一29)inchronichepatitisB，cirrhosis，hepatocellularcarcinomapatientswerelowerthanthatinthecontrols(P<0．01)andchronicHBVcarriers，(P<0．01)．Therewasnosignificantdifferencebetweenchroni

7、cHBVcarriersandnegativecontrols(P>0．05)．Nosignifi—cantdifferencewerefoundinIFN—k2(IL-28A)ofallfivegroups(P>0．05)．ThelevelofIFN—k3inhepato-cellularcarcinomapatientswasthehighestamongallgroups．ConclusionIFN—kllevelisdecreasedinchron—icHBVinfectionpatientswhencomparedwi

8、thhealthypeople．Inaddition，highlevelofserumIFN—k3mayberelatedtotheoccurrenceofhepatocellularcarcinoma．【Keywords】TypeIIIinterferon；C