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时间:2017-12-07
《不同时期慢性hbv感染者血清ifn-λs水平的变化》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、新医学2014年2月第45卷第2期119临床研究论著不同时期慢性HBV感染者血清IFN—ks水平的变化杜以真王晓花张孝国张纵阚晓徐皖苏【摘要】目的了解不同时期慢性HBV感染者血清IFN—ks水平,探讨其变化与慢性HBV感染进程的关系。方法选择120例慢性HBV感染者,其中HBV携带者、慢性乙型病毒性肝炎(慢乙肝)患者、乙肝肝硬化患者、HBV相关肝癌患者各30例,以20名健康人为对照。采用双抗体夹心ELISA法,检测各组研究对象血清IFN—ks(IL一29、IL-28A和IL一28B)水平。结果慢乙肝、乙肝肝硬化、HBV相关肝癌患者的血清IFN—hl(IL-29)水平均明显低于健康对照组(P均
2、<0.O1),慢乙肝、乙肝肝硬化、HBV相关肝癌患者血清IFN—kl(IL一29)水平明显低于HBV携带者(尸均<0.01);HBV携带者血清IL一29水平与健康对照组相近(P>0.05)。各组慢性HBV感染患者的血清IFN—k2(IL一28A)水平与健康对照组比较均无统计学意义(P>0.05)。HBV相关肝癌患者血清IFN一3(IL-28B)水平高于健康人、HBV携带者、慢乙肝患者、乙肝肝硬化患者(P均<0.01);HBV携带者、慢乙肝、乙肝肝硬化和健康对照组间血清IL-28B水平比较差异无统计学意义(P>0.05)。结论慢性HBV感染者血清IFN—kl(IL-29)水平明显下降,而且HB
3、V相关肝癌患者血清IFN—k3(IL一28B)的水平明显升高,可能与肝癌的发生有关。【关键词】血清Ⅲ型干扰素;慢性HBV感染;白细胞介素Seruminterferon-lambdaofdiferentstagesinpatientswithchronicHBVinfectionDUYi—zhen.WANGXiao—hua,ZHANGXiao—guo,ZHANGZo,KANXiao,XUWan—sJinanInfectiousDiseaseAffiliatedttospi一£0fofShandongUniversity.Ji~an250021,ChinaCorrespondingauthor,
4、XUWan—SU,E—mail:xuwamudyz@163.corn【Abstract】ObjectiveTostudyIFN—kslevelsinpatientswithchronichepatitisBvirus(HBV)in—fections,andinvestigatetherelationshipbetweenhumantypeIIIinterferons(IFN—ks)andchronicHBVinfec·tion.Methods120chronicHBVinfectionpatientswererecruited,anddividedinto4groups:chronicHBV
5、carriers,chronichepatitisBpatients,HBVrelatedcirrhosisandHBVrelatedhepatocellularcarcinomapa—tients.20healthypeoplewereasnegativecontrols.IFN—kslevelsweredetectedbyEnzyme—linkedimmunosor—bentassay(ELISA).ResultsLevelsofIFN-kl(IL一29)inchronichepatitisB,cirrhosis,hepatocellularcarcinomapatientswerelo
6、werthanthatinthecontrols(P<0.01)andchronicHBVcarriers,(P<0.01).TherewasnosignificantdifferencebetweenchronicHBVcarriersandnegativecontrols(P>0.05).Nosignifi—cantdifferencewerefoundinIFN—k2(IL-28A)ofallfivegroups(P>0.05).ThelevelofIFN—k3inhepato-cellularcarcinomapatientswasthehighestamongallgroups.C
7、onclusionIFN—kllevelisdecreasedinchron—icHBVinfectionpatientswhencomparedwithhealthypeople.Inaddition,highlevelofserumIFN—k3mayberelatedtotheoccurrenceofhepatocellularcarcinoma.【Keywords】TypeIIIinterferon;C
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