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时间:2020-04-23
《不同超声参数对肿瘤细胞生长的抑制作用-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、·1504·任淑婷,等不同超声参数对肿瘤细胞生长的抑制作用不同超声参数对肿瘤细胞生长的抑制作用任淑婷,廖怡然,齐超,康小宁,张卉,赵兴华,李红丽,孙彭菲,王冰,TheinhbiflingefectofdiferentultrasoundparametersontumorcellgrowthRenShuting,LiaoYiran,QiChao,KangXiaoning,ZhangHui,ZhaoXinghua,LiHongli。,SunPengfei,WangBing’DepartmentofP
2、athology,SchoolofMedicine,Xi'anJiaotongUniversity,ShaanxiXi"an710061,China;TherapeuticVaccinesEngineer-ingCenterofShaanxiProvince,ShaanxiXi'an710061,China;DepartmentofPharmacology,SchoolofMedicine,Xi"anJiaotongUniversi—ty,ShaanxiXi"an710061,China;Xi"
3、anNorthCentralHospital,ShaanxiXi"an710032,China;ElementaryDepartment2,ShaanxiEner-gYInstitute,ShaanxiXi"an710613,China;。DepartmentofPharmacy,SchoolofMedicine,Xi"anJiaotongUniversity,ShaanxiXi"an710061,China;FirstAssociatedHospital,SchoolofMedicine,Xi
4、"anJiaotongUniversity,ShaanxiXi"an710061,China;WorkerHospital,the205thResearchInstitute,ChinaOrdnanceIndustry,ShaanxiXi"an710065,China.【Abstract】0bjective:Toexploretheeffectofdifferentultrasoundparametersontumorcellgrowthandprovidetheexperimentaldata
5、forultrasoundcombinedwithmicrobubbles—loadeddrugintumortherapy.Methods:Basesonthreefactorsoftheultrasonicintensity(1.48W/cm,2.56W/cm,2.79W/cm),dutycycle(1:5,1:1,5:1)andul—trasonicexposuretime(5mins,10mins,15mins),ninegroupsweredesignedbyorthogonalmet
6、hodsintheSKOV3celllineandMCF一7celllinewithdifferentultrasonictreatmentaswel1asthecontrolgroup(withoutanytreatment)wasdesigned.TheirgrowthinhibitionratewasevaluatedbyMTTassayandthesethreeparameterswereinturnanalyzed.Results:Comparedwiththecontrolgroup
7、,thecellulargrowthinhibitionwerenotobservedintwocelllinesatthedutycyclesof1:1and1:5.However,thecellulargrowthinhibitionratesweremorethan90%(P<0.05)inthreegroupsofSKOV3celllineatthedutycycleof5:1whileitwas48.8%.55.4%and88.7%inthreegroupsofMCF一7celllin
8、erespectively(尸<0.05).Factorialanalysisshowedthreeultrasonicparametershadinteractioneffectonthecellu—larviabilityinSKOV3celllineandMCF一7cellline,butthedutycycleoftheuhrasoundwasthemostimportantfac—tot.Conclusion:Theroleofdifierentultrasoundparameters
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