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《变应性鼻炎患者血清白细胞介素含量检测及临床价值-论文.pdf》由会员上传分享,免费在线阅读,更多相关内容在行业资料-天天文库。
1、海南医学院学报2014,20(5)700JournalofHainanMedicalUniversityDOI:10.13210/j.cnki.jhmu.20140124.082网络出版地址:http://www.cnki.net/kcms/doi/10.13210/j.cnki.jhmu.20140124.082.html变应性鼻炎患者血清白细胞介素含量检测及临床价值阙镇如,冉骞,林丹琪,张智斌,蔡继一,许玉,黄钦辉(解放军第180医院耳鼻咽喉科,福建泉州362008)[摘要]目的:研究变应性鼻炎患者血清白细胞介素含量及临床价值。方法:选取在我院就诊的变应性鼻炎患者纳入研究的观察组,同期在我
2、院接受体检的健康者纳入研究的对照组,检测血清白细胞介素一4(IL一4)、白细胞介素-5(IL一5)、白细胞介素一17(IL一17)、白细胞介素一33(IL一33)含量以及气道功能指标,并进行临床症状评分。结果:(1)观察组的IL一4、IL一5、IL一17、IL一33水平高于对照组;(2)观察组的最大呼气流速(PEF)、一秒率(FEV1/FVC)均低于对照组,喷嚏、流涕、鼻塞、鼻痒评分均高于对照组;(3)血清IL一4、IL一5、IL一17、IL-33水平与PEF、FEV1/FVC呈负相关,与喷嚏、流涕、鼻塞、鼻痒评分呈正相关。结论:血清白细胞介素含量且具有检测方便、客观性强的优势,能够便捷、准确
3、、客观的反应变应性鼻炎患者的整体病情,临床应用价值明确。[关键词]变应性鼻炎;白细胞介素;气道功能[中图分类号]R765.21[文献标识码]B[文章编号]1007—1237(2014)05—0700—04SeruminterleukinlevelsinallergicrhinitispatientsanditsclinicalvalueQUEZhen—FH,RANQian,LINDan—qi,ZHANGZhi—bin,CAIJi—Yi,XUYu,HUANGQin—hui(Departmentof0£0rn0£nrg0Z0g,Quanzhou180HospitalofPLA,Quanzhou36
4、2008,China)[FoundationBect]:ScienceandTechnology&口“of@anzho~(2012z59)[Author]:QUEZhen—rbt(1964一),Male,YongdingFujian,M.B.,DeputyChiefPhysician,Tel:13313835711,E-mail:qzrl80@163.com.Received:2014—01—15Revised:2O14—01—21JHMC,2014;20(5):700—703Viewfromspecialist:Itiscreative,andofcertainscientifieanded
5、ucationalvalue.[ABSTRACT]Objective:Toinvestigatetheseruminterleukinlevelsinallergicrhinitispatientsanditsclinicalvalue.Methods:Allergicrhinitispatientsadmittedtoourhospitalwereenrolledasobservationgroupandhealthypeopleunderwentphysicalexaminationwereenrolledascontrolgroup.ThenserumIL一4,IL一5,IL一17,II
6、一33contentandairwayfunctionweredetected,clinicalsymptomscorewereevaluated.Results:(1)IL一4,IL一5,IL一17,IL一33contentsofobservationgroupwerehigherthanthoseofcontrolgroup;(2)PEF,FEV1/FVCofobservationgroupwerelowerthanthoseofcontrolgroup,nasalitch—ing,nasalcongestion,runnynose,sneezingscoreofobservationgr
7、oupwerehigherthanthoseofcontrolgroup;(3)II一4,II一5,IL一17,IL一33contentswerenegativelycorrelatedwithPEF。FEV1/FVCandposi—tivelycorrelatedwithnasalitching,nasalcongestion,runnynose,sneezingscore.Conclusion
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