芬太尼不同给药速度对诱发咳嗽反应的影响-论文.pdf

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1、2014年2月第12卷第4期·论著·41芬太尼不同给药速度对诱发咳嗽反应的影响潘明谢丹苗壮。(1大连市中心医院麻醉科，辽宁大连116000；2大连医科大学附属第一医院麻醉科，辽宁大连116000)【摘要】目的观察麻醉诱导时不同给药速度输注芬太尼对诱发咳嗽反应(fentanylcoughreflx，FCR)的影响，选择最佳的给药速度。方法选择择~4-g-60例全麻患者随机分成3组：I组30S内经静脉直接注射芬太尼4p,g／kg；II组以120滴的滴速滴入芬太尼4g，kg；II组以6O滴的滴速滴入芬太尼4~tg／kg；记录患者是否发生咳嗽

2、及呛咳的程度。并同时记录芬太尼注射前、后的血压、心率、呼吸和脉搏血氧饱和度，以及药物不良反应。结果I组患者FCR发生率为75％，I】组为5％，三组为0，且i组的呛咳程度显著高于II组(P

3、4)04—0041—02FentanyltheInfluenceofDiferentDosingSpeedResponsetoInduceCoughPANMing1XIEDan1，MIA0Zhuang2flDepartmentofAnesthesiology,DalianMunicipalCentralHospital,Dalian116000,China；2DepartmentofAnesthesiology,FirstAfiliatedHospitalofDalianMedicalUniversity,Dalian116000,C

4、hin【Abstract】ObjectiveToobserveanesthesiainduceddiferentdosingspeedinfusionoffentanylinducedcoughresponse(fentanylcoughreflx，FCR)，theinfluenceofselectingthebestdrugdeliveryspeed．Methods60patientswithgeneralanesthesiawererandomLydivide~linto3groupselectivesurgicalprocedu

5、res：Igroup30secondscanonveininjectedfentanyl(including4／~g／kg；Ⅱgroupin120thedropdropsintofentanyl(including4g；Ⅲgroupto60ofthedrippingspeeddropsintothefentanyl(including4~tg／kg)；recordwhetherpatientswiththeextentofthecoughingandchoking．Andatthesametimerecordoffentanylinj

6、ectionbeforeandafterthebloodpressure，heartrate，breathingandpulseoxygensaturation，andadversedrugreactions．ResultsIgrouppatientswas75％，incidenceofFCRⅡgroupwas5％，thethreegroupsof0，andthedegreeofchokingcoughIgroupissignificantlyhigherthanIIgroup(P<0．O1)．Igroupafterdosingmor

7、eassociatedwithanincreaseinheartrateincreasefast，bloodpressure，comparedwiththeothertwogroupshadsignificantdiference<0．05)．ConclusionViaperipheralveinwithin30secondsofdirectinjectionoffentanyl(including4／．tg／kg)，highincidenceofFCR，120and60dropsdripfentanylsidetubesignifi

8、cantlyreducetheincidenceofpatientswithcoughordoesn’thappen,toimprovethesafetyofanesthesia．1KeywordslFentanyl；F