不同靶浓度的瑞芬太尼用于七氟醚吸入诱导的对比观察-论文.pdf

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1、中国实用医药2014年2月第9卷第6期ChinaPracMed，Feb2014，Vo1．9。No．6·39·[5]宋纪军，刘宏建．不同术式及材料鼓膜成形术的疗效观察．听力学及言语疾病杂志，2013，21(3)：287—288t不同靶浓度的瑞芬太尼用于七氟醚吸入诱导的对比观察幸芳周东民曹丽艳【摘要】目的在脑电双频指数(BIS)的监测下，比较不同血浆靶浓度的瑞芬太尼复合七氟醚麻醉诱导对血流动力学的影响，探讨瑞芬太尼合适的麻醉诱导剂量。方法择期全麻手术患者60例。按瑞芬太尼靶浓度不同随机分为3组：3ng／~(D1组)

2、、4ng／ml(D2组)和5ng／ml(D3组)，每组20例。3组均采用七氟醚吸人麻醉诱导。当BIS值达6O时静注顺式阿曲库铵辅助插管。分别记录诱导前011、插管前02)、插管即刻3)、插管后3rain04)的平均动脉压(MAP)和心率(HR)，以及各组患者意识消失的时间。结果与T1相比，tI12各组MAP和HR均有下降，但D3下降更明显(P

3、更平稳，此剂量的瑞芬太尼为合适的诱导剂量。【关键词】靶控输注；瑞芬太尼；七氟醚；吸入诱导Observationofdifferentplasmaconcentrationofremifentanilcombinedwithsevofluraneininhalation，generalanesthesiainductionXINGFang,ZHOUDong-min,CAOLi-yan．TumorHospitalAfiliatedtoHenan幻ersyMedicalCollege，Zhengzhou450008,

4、China．【Abstract】objectiveThisexperimentwast~ingtocomparethehemodynamiceffectofpatientswithgeneralanesthesiainductionofsevofluranecombinedwithdifferentremifentanilplasmaconcentrationundermonitoringofbispectralindex(BIS)．Andtofigureouttheproperdosageofremifent

5、anilforgeneralanesthesiainduction．MethodsSixtypatientswaitingfortheselectiveoperationwithgeneralanesthesiawereseparatedrandomlyinto3groupsaccordingtotargetplasmaconcentrationofremifentanih3ng／ml(D1)、4ng／ml(D2)and5ng／ml(D3)，(n=2Oeach)．Allof3groupscombinedwith

6、sevofluraneforthegeneralanesthesiainduction．andtooktrachealintubationafterCisatracuriumBesilateinjectionwhenBIScameto60．Torecordthemeanbloodpressure(MAP)，heartrate(HR)atthetimepointsofbeforeanesthesiainduction(T1)，beforeintubation(T2)，intubationtime(T3)，3min

7、afterintubation04)andtorecordthetimeofconsciousnesslost．ResultsComparedwiththetimepointsofbeforeanesthesiainduction01)，themeanbloodpressure(MAP)andheartrate(HR)ofallthe3groupsatthetimepointsofbeforeanesthesiainduction01)waslower．andparticularlyevidentinD3(P<

8、0．05)．TheMAPandHRofD1group’Spatientsatthetimepointsofintubationtime03)weremarkedlyfasterthanthatatthetimepointsofbeforeanesthesiainduction(T1)，beforeintubation02)(P<0．05)．Therewasnosignificantdi