择时服用扶正祛邪抗癌方对小鼠化疗造血功能的影响.pdf

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1、中国中医基础医学杂志2014年4月第2O卷第4期452ChineseJournalofBasicMedicineinTraditionalChineseMedicineApril2014Vo1．2O．No．4【实验研究】择时服用扶正祛邪抗癌方对小鼠化疗造血功能的影响来顾检波，王秀，李艳△(1．江苏省常熟市支塘人民医院，江苏常州215500；2．皖南医学院，安徽芜湖241002；3．皖南医学院附属戈矶山医院，安徽芜湖241001)摘要：目的：观察择时服用扶正祛邪抗癌方对顺铂化疗后Lewis肺癌荷瘤小鼠造血功能的影响。方

2、法：对适应明暗交替环境的C57BL／6小鼠进行Lewis肺癌造模，按随机数字表法分成6组，遣模成功5d后开始按不同时辰给予扶正祛邪抗癌方和化疗药，给药2周后同时处死并采取血液等样本检测相关指标。结果：与化疗组比较，各时辰用药组白细胞和红细胞以及骨髓有核细胞计数出现一定回升(P<0．05)，时辰用药组间比较，亥时组白细胞计数以及骨髓有核细胞计数回升明显(P<0．05)，而各时辰组红细胞回升差异无统计学意义。结论：扶正祛邪抗癌方可改善Lewis肺癌小鼠化疗引起的骨髓抑制，择时服用该药对骨髓抑制的恢复亦不尽相同，亥时用药对

3、改善化疗引起的骨髓抑制最为明显。关键词：扶正祛邪抗癌方；顺铂；Lewis肺癌小鼠；择时用药中圈分类号：R730．52文献标识码：B文章编号：1006-3250(2014)04-0452-03InfluenceofFuzhengQuxieAnticancerPrescriptiontakingbychoosingthetimeonthechemotherapyandhematopoieticfunctioninmiceGUJian．boI，WANGXiu，LIYan(1．JiangsuProvinceChangzhou

4、CityBranchTangPeople’sHospital，JiangsuChangzhou215500，China；2．WannanMedicalCollege，AnhuiWuhu241002，China；3．zeGejishanHospitalAffiliatedtoWannanMedicalCollege，Anhuiu241000，China)Abstract：0bjective：ObservetheresearchonthehematopoieticeffectoftakingFuzhengQuxieKan

5、gaifang(FXKAF)timingandCisplatin(DDP)inthetreatmentoftumor．beatingmicewithLewislungcancer．Methods：MakeC57BL／6micewithLewislungcancermodelafteritsadapttotheahematinganddarkenvironment．Thenrandomlydividedthemiceinto6groups．AccordingtothediferenttimetosuitthemiceF

6、XKAFandchemotherapydrugaftertheSUCCESSofmodeling．Aftertwoweeksofadministration．themicewerekilledattIlesametime，andthentaketherelatedindexesofbloodsamples．Results：Comparedwiththechemotherapygroup，thewhitebloodcellsandredbloodcellsandbonemarrownucleatedcellcounto

7、feachhourmedicationgroupwerecertainlyfised(P<0．05)，comparethehourgroup，the9P．m．to11P．mgroup’swhitebloodcellandbonemarrownucleatedcellcountrisedsignificantly(P<0．05)，andtheredbloodcellcounthadnoobviouslydifference(P>0．05)．Comparedwiththemodelgroup，thechemotherap

8、ygroup’sEPOandG-CSFcontentdecreased(P<0．05)．Andeachhourgroup’sG—CSF，EPOcontentvaryingrised．Comparethehourgroup，the9P．m．to11P．mgroup’sG—CSFincreasedsignificantly(P<0．05)．Conc