药物不同应用方式对肺癌治疗影响分析.pdf

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1、中国肿瘤临床与康复2014年4月第21卷第4期ChinJClinOncolRehabil，April2014，Vol21，No．4·临床应用·药物不同应用方式对肺癌治疗影响分析李建安(广西科技大学第二附属医院化疗科，柳州545006)【摘要】目的探讨对比同一药物采用静脉全身化疗与经动脉灌注局部化疗治疗肺癌的效果。方法160例肺癌患者根据入院顺序分为治疗组与对照组各8O例，两组均选择顺铂化疗，对照组采用传统静脉全身用药，治疗组采用经动脉灌注局部化疗。结果治疗组有效率为8O．0％，对照组为55．0％，两组患者有效率差异有统计学意义(P<0．05)。两组患者化疗前功能状态(KPS)评分对比

2、无明显差异，化疗组间与组内比较差异有统计学意义(P<0．05)。随访6个月，治疗组恶心、呕吐、食欲减退等总体并发症发生率明显低于对照组(P<0．05)。随访2年，治疗组的平均生存期、1年生存率和2年生存率都明显高于对照组(P<0．05)。结论经动脉灌注局部顺铂化疗相较于静脉全身化疗，可提高肺癌的治疗效果，减轻症状，降低不良反应，提高远期生存率，有很好的临床应用价值。【关键词】肺肿瘤；经动脉灌注局部化疗；静脉全身化疗；顺铂【DOI】10．13455／j．cnki．cjcor．2014．04．26【中图分类号】R734．2【文献标识码】ATheefectsofdiferentapplic

3、ationsofthesamedrugforthetreatmentoflungcancerLlJiart—art(DepartmentofChemotherapy，TheSecondAfiliatedHospitalofGuangxiTechnologicalUniversity，Liuzhou545006，China)【Abstract】0bjectiveToinvestigateefectsofdiferentapplicationsofthe8anledrugforthetreat—mentoflongcancer．Methods160eo~esoflungcancerpat

4、ientswereequallydividedintotreatmentgroupandcontrolgroupaccordingtothesequenceofhospitalization(80casesforeachgroup)．Thetwogroupsalladoptedcisplatinforchemotherapy，butthecontrolgroupselectedtraditionalintravenoussystemicadminis-tration，andthetreatmentgroupintravenoussystemicchemotherapy．Results

5、Theefectiverateofthetreat—mentgroupwas80．O％．andtheotherwas55．0％．ThereWassignificantdiferencebetweenthetwogroups(P<0．05)．theKPSscorehadnosignificantdifferencebeforechemotherapyandweresignificantlydifferentafterchemotherapy(P<0．05)．Afterfollow—upof6months，thenausea，vomiting，lossofappetiteetcover-

6、allcomplicationrateofthetreatmentgroupWassignificantlylessthanthecontrolgroup(P<0．05)．AfterFollow—upof2years，theaveragesurvivalperiod，1-yearsurvivaland2-yearsurvivalratesofthetreatmentgroupweresignificantlyhigher(P<0．05)．ConclusionComparedwithintravenouschemotherapy，arteri—alinfusionchemotherap

7、yappliedthetreatmentoflungcancercanimpmveeficacy，relievesymptoms，reducetoxicityandimprovelong—termsurvival，whichhasbetterclinicalvalue．【Keywords】Lungneoplasms；Aaerialinfusionoflocalchemotherapy；Intravenoussystemicchemotherapy；Cisp