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《叶酸、维生素b6、甲钴铵联合门冬胰岛素治疗妊娠糖尿病合并高同型半胱氨酸血症患者的疗.doc》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、叶酸、维生素B6、甲钻钱联合门冬胰岛素治疗妊娠糖尿病合并高同型半胱氨酸血症患者的疗效观察［摘耍］目的探讨叶酸、维生素136、甲钻鞍联合门冬胰岛素治疗妊娠糖尿病（GDM）合并高同型半胱氨酸血症（HHcy）患者的疗效及围生儿预后的影响。方法选择68例GDM合并Illlcy孕妇，按随机抽样的方法随机分为治疗组和对照组。对照组34例在一般治疗基础上加用门冬胰岛素治疗，治疗组34例在对照组基础上给予维生素B610ing/d、叶酸5mg/d.甲钻鞍500Ug/do结果治疗前后患者血糖、血浆Hey浓度下降幅度治疗组明显高于对照组，差异有统计学意义（PC0.05）。围生儿结局：巨大儿、低血糖、低钙血症
2、、高胆红索血症、红细胞增多症发生率治疗组明显低于对照组，差异有统计学意义（P<0.05）o结论叶酸、维生素B6、甲钻钱联合门冬胰岛素能够较好控制GDM合并HHcy患者血糖、降低血浆同型半胱氨酸水平，减少I韦I产儿并发症，而且安全性好，值得临床推广应用。［关键词］叶酸；维生素B6；甲钻發门冬胰岛素；妊娠糖尿病；高同型半胱氨酸血症［屮图分类号］R743.3［文献标识码］A［文章编号］1674-0742(2013)06(c)-0129-03TheClinicalResearchofCombinationofFolicacid,VitaminB6,MethylcobalaminandInsul
3、inaspartinPatientswithGestationalDiabetesMel1itusandHyperhomoeysteinemiaZIIAOBingkunXUXiufangCAIXingliDepartmentofGynaecologyandObstetrics,TheRailwayHospitalofShaoguanCity,Shaoguan512023,China[Abstract]ObjectiveTnvestigatethetreatmentofgestationaldiabetesmellitus(GDM)offolicacid,vitaminB6,methyc
4、obaljointinsulinaspartwithhyperhomocysteinemia(IHIcy)prognosisofpatientstheefficacyandperinatalchildren.MethodsSelect68casesofGDMmergerHHcypregnantwomenwererandomlydividedintoatreatmentgroupandacontrolgroup,accordingtothemethodofrandomsampling・Thecontrolgroupof34patientsonthebasisofthegeneraltre
5、atmentplusinsulinaspart,Treatmentgroup,34patientsonthebasisofthecontrolgroupplusvitaminB610mg/d,folicacid5ing/d,methycobal500ug/d.ResultsBloodglucose,plasmaHeyconcentrationsbeforeandaftertreatment,todeclinesignificantlyhigherintheztreatmentgroup(P<0.05)・Perinatalchildoutcome:hugechildren,hypogly
6、cemia,hypocalcemia,hyperbilirubinemia,polycythemiadiseaseincidenceoftreatmentgroupwassignificantlylowerthanthecontrolgroup.Thedifferencewasstatisticallysignificant(卩<0.05)•ConelusionFolicacid,vitaminB6,MethycobaljointaspartinsulintobettercontroltheGDMmergerIHIcybloodsugar,reduceplasmahomocystein
7、elevels,reduceperinatalcomplications,andthesecurityisgood,worthyofclinicalapplication.[Keywords]Folicacid；Vitaminb6；Methycobal；InsulinAspart；Gesteitionaldiabetesmellitus；Hyperhomoeysteinemia妊娠糖尿病(GDM)指妊娠前无糖尿病和糖耐量界常，在妊娠期发生或首次
