[精品]吡格列酮联合二甲双胍治疗老年2型糖尿病的临床观察.doc

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1、毗格列酮联合二甲双肌治疗老年2型糖尿病的临床观察毗格列酮联合二甲双弧治疗老年2型糖尿病的临床观察摘耍：目的探讨毗格列酮联合二甲双弧治疗老年2型糖尿病的临床疗效。方法选取我院2009年3月〜2013年3月收治的120例老年糖尿病患者的临床资料，随机分为治疗组(60例)和对照组(60例)，对照组采用常规治疗，治疗组患者在对照组治疗的基础上联合毗格列酮治疗，连续治疗12w,观察两组患者空腹血糖(FBG)、餐后2h血糖(PBG)、胰岛素敏感指数、肾功能改变情况。结果在治疗12w之后，治疗组患者的空腹血糖和餐后2h血糖改

2、善明显优于对照组患者，两组患者疗效比较差异有统计学意义(P<0.05)o治疗组患者胰岛素敏感指数低丁对照组，两组患者比较差异有统计学意义(P<0.05),治疗组患者UAER及ET-1均显著低于对照组患者，两组患者比较斧异有统计学意义(P<0.05)o结论毗格列酮联合二甲双弧治疗2型糖尿病，降糖效果好，可改善患者的胰岛素抵抗，减少微量蛋白的排泄，疗效满意值得在临床推广。关键词：毗格列酮；二甲双弧；糖尿病；临床疗效ClinicalObservationofPioglitazoneCombinedwithMetfor

3、minintheTreatmentofElderlyPatientswithType2DiabetesFUXian,LTANGXiu-zhen,LIUHong(TheFirstSocialWelfareInstituteofBeijingCity/BeijingGeriatricsHospital,Beijing100029,China)Abstract：Object!veToinvestigatethepioglitazonejointmetformintreatmentofseniletype2clinic

4、alcurativeeffect・MethodsSelectourMarch2009、inMarch2010were120casesofelderlypatientswithdiabetes,theclinicaldatawererandomlydividedintothetreatmentgroup(n=60)andthecontrolgroup(n=60),weretreatedbyconventionaltreatment,thetreatmentgroupsofpatientsinthecontrolg

5、rouptreatmentbasedonjointpioglitazonetreatment,continuoustTestment12weeks,observethetwogroupswerefastingplasmaglucose(FBG)and2~hrplasmaglucose(PBG),insulinsensitivityindex,kidneychange・Resultslnthetreatmentof12weeksaftertreatmentgroupsofpatientsfastingglucos

6、eand2~hrplasmaglucoseimprovesignificantlybetterinpatients,twogroupsofpatientswasstatisticallysignificanteffectcomparativedifferences(P<0・05)・Thetreatmentgroupwaslowerinpatientswithinsulinsensitivityindex,twogroupsofpatientswerecomparedwithadifferencewasstati

7、sticallysignificant(P<0.05),thetreatmentgrouppatientsUAERandET-1weresignificantlylowerthanthecontrolgrouppatients,twogroupswerecomparativedifferencesarestatisticallysignificant(P<0・05).ConclusionPioglitazonejointmetformintreatmentfortype2diabetes,hypoglycemi

8、ceffectisgood,canimprovepatientswithinsulinresistance,reducetraceproteinexcretion,andtheresultsweresatisfactoryworthinclinicalpromotion.Keywords：PioglitazonejMetformin;Diabetes;Clinicalcurativee