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1、硫辛酸治疗糖尿病足的临床观察硫辛酸注射液治疗糖尿病足的临床观察张继刚臧义献咨询：029-3205-6936186-9106-9128摘耍：目的：为了观察硫辛酸对糖尿病足(DF)的临床疗效，并评估其安全性。方法：对符合WH0DF的诊断标准98例糖尿病足患者，随机分为两组：治疗组50例，空腹血糖(11.6±3.0)mmol/L；对照组48例，空腹血糖(11.2±2.8)mmol/Lo对照组给予糖尿病基础治疗(包括饮食控制、胰岛素控制血糖，有效抗生素控制感染，减压治疗，外科治疗)；治疗组在上述基础上加用硫辛酸600吨注射液静
2、滴,每日1次，共28天。结果：在临床疗效方面治疗组比对照组具有显著性差异，在足背血流动力学方而治疗组治疗前血流速度(m/(s.mm)为0.34+0.13,治疗后血流速度〔m/(s.inm)为0.84±0.16,对照组治疗前血流速度Im/(s.inin)0.35±0.18,治疗后血流速度5/(s.mm)为0.61±0.11(p<0.01),在神经传导方面腓总神经Mcv(±s,m/s)治疗组治疗前38.13±4・51,治疗后43.67±4.20；对照组治疗前38.70±4.42,治疗后43.67±4.20(p<0.05),
3、腓浅神经Scv(±s,m/s)治疗组治疗前36.76±1.89,治疗后42.12±3.16；对照组治疗前37.13±1.86治疗后39.32±2.78(p<0.05)传导速度方面均有明显改善。结论：该研究说明硫辛酸注射液在治疗糖尿病足方面疗效显著，并能改善足背血流动力学和腓总神经及腓浅神经传导速度，具有良好的临床效果。关键词：糖尿病足；硫辛酸；临床观察Abstract:Objective:Toobservethelipoicacidondiabeticfoot(DF)oftheclinicalefficacyandto
4、assesstheirsafety・Methods:ThediagnosticcriteriaconsistentwithWHODF98casesofdiabeticfootpatientswererandomlydividedintotwogroups:thetreatmentgroupof50patients,fastingbloodglucose(11.6±3.0)mmol/L;thecontrolgroup48patients,fastingbloodglucose(11.2±2.8)mmol/L.Contro
5、lgroupwasgivenbasictreatmentofdiabetes(includingdietcontrol,insulincontrolbloodsugar,theeffectiveantibioticstocontrolinfection,decompress!ontherapy,surgicaltreatment);treatmentgroupbasedontheaboveplus1ipoicacid600mgintravenousinjection,1day,atotalof28days・Result
6、s:Theclinicalefficacyinthetreatmentgroupthaninthecontrolgroup,significantdifferencesindorsalhemodynamicsbeforetreatment,bloodflowvelocity(m/(s.mm)was0.34±0.13,aftertreatment,bloodflowvelocity(m/(s.mm)was0.84±0.16,controlgroup,bloodf1owvelocitybeforetreatment(m/(
7、s.mm)0.35±0.18,aftertreatment,bloodflowvelocity(m/(s.mm)was0.61±0.11(p<0.01),nerveconductionvelocityintheperonealnerveMcv(±s,m/s)beforetreatment,38.13±4.51,aftertreatment43.67±4.20;controlgroupbeforetreatment38.70±4.42,aftertreatment43.67土4.20(p<0.05),superficia
8、lperonealnerveScv(+s,m/s)beforetreatment,36.76±1.89,aftertreatment42.12土3.16;controlgroup,37.13土1.86beforetreatmentAftertreatment,39.32±2.78(p〈0.05)weresignificantlyi
