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时间:2020-04-06
《特利加压素治疗难治性感染性休克患者的临床效果.doc》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、特利加压素治疗难治性感染性休克患者的临床效果[摘要]目的探讨特利加压索对难治性感染性休克患者心指数、外周循环阻力的影响。方法选取我院2011年1月〜2014年1月收治入院的感染性休克患者作为研究对象,所有患者给予积极体液复苏并使用大剂量去甲肾上腺索治疗,其中88例感染性休克患者循环仍难以维持,临床给于加用特利加压素(125Mg/h),观察患者治疗前后平均动脉压、脉搏、心指数、外周循环阻力指数、尿量、血肌断、尿素氮等指标。结果患者治疗后6、12、24、48hMAP.SVRT均明显高于治疗前,而HR、CI等指标治疗后12、2
2、4、48h明显低于治疗前,去甲肾上腺素用量明显低于治疗前,差异有统计学意义(P〈0・05);治疗后第1、3、7天尿量明显高于治疗前,而血肌酊、尿素氮在治疗后第3、7天时明显低于治疗前,差异均有统计学意义(PC0.05)。结论特利加压索应用于难治性感染性休克能够改善心指数和外周循环阻力,临床效果显著,可在临床广泛推广。[关键词]感染性休克;特利加压索;二氧化碳分压;多巴胺[中图分类号]R631+.4[文献标识码]A[文章编号]1674-4721(2016)02(b)-0116-03Clinicaleffectofterli
3、pressinontreatingpatientswithintractablesepticshockLINFengZENGYa-jingJIANGYueDepartmentofIntensiveCareUnit,People'sHospitalofYangjiangCityinGuangdong卩rovince,Yangjiang529500,China[Abstract]ObjectiveToexploretheinfluenceofterlipressinoncardiacindexandperipheralvas
4、cularresistaneeinpatientswithintractablesepticshock.MethodsFromJanuary2011toJanuary2014,patientswithsepticshocktreatedandadmittedintoourhospitalwereselectedasresearchobjects.Allpatientswerepositivelyprovidedwithfluidresuscitationandhighdosageofnorepinephrinefortr
5、eatment.Amongthem,therewere88septicshockpatientswhosecirculationwashardtomaintain,and125ug/hterlipressinwasaddedinclinic6、reandaftertreatmentwereobserved.ResultsMAPandSVRI6,12,24,and48hoursaftertreatmentweremuchhigherthanthosebeforetreatmentsandHRandCI12,24,and48hoursaftertreatmentweregreatlylowerthanthosebeforetreatment.Thedosageofnorepinephrineusedwasobviouslylowerthanthatbeforead7、dingnorepinephrine,whichalldisplayedstatisticaldifferenee(P<0.05)•1,3,and7daysaftertherapy,volumeofurinewasmuchmorethanthatbefore,andserumcreatinine,bloodureanitrogen3and7daysaftertreatmentweremuchlowerthanthosebeforetreatmentwithstatisticaldifference(P<0.05)•Con8、clusionAdditionalapplicationofterlipressintotreatintractablesepticshockcanimproveCTandSVRTinaremarkableclinicaleffect,whichisworthyofexpansivepromotioninclinic
6、reandaftertreatmentwereobserved.ResultsMAPandSVRI6,12,24,and48hoursaftertreatmentweremuchhigherthanthosebeforetreatmentsandHRandCI12,24,and48hoursaftertreatmentweregreatlylowerthanthosebeforetreatment.Thedosageofnorepinephrineusedwasobviouslylowerthanthatbeforead
7、dingnorepinephrine,whichalldisplayedstatisticaldifferenee(P<0.05)•1,3,and7daysaftertherapy,volumeofurinewasmuchmorethanthatbefore,andserumcreatinine,bloodureanitrogen3and7daysaftertreatmentweremuchlowerthanthosebeforetreatmentwithstatisticaldifference(P<0.05)•Con
8、clusionAdditionalapplicationofterlipressintotreatintractablesepticshockcanimproveCTandSVRTinaremarkableclinicaleffect,whichisworthyofexpansivepromotioninclinic
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