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1、阻塞性睡眠呼吸暂停低通气综合征患者血清IL—6、IL—17水平变化及临床意义【摘要】日的：探讨阻塞性睡眠呼吸暂停低通气综合征(Obstructivesleepapnea-hypopneasyndromes,OSAHS)患者血清炎性因子白细胞介素_6(Interleukin,IL-6)、白细胞介素-17(Interleukin,IL-17)水平变化及临床意义。方法：回顾性分析2013年5月-2014年10月间本院呼吸科门诊及住院部经多导睡眠图(Polysoninagraphy,PSG)监测确诊的102例OSAHS患者,及同期本院
2、体检中心98例健康体检者的一般临床资料、睡眠呼吸暂停低通气指数(Apnea-hypopneaindex,AHI)、最低血氧饱和度(Lowestarterialoxygensaturation,LSaO2)0米集静脉血，分离血清，酶联免疫吸附法(Enzyme-linkedimmunosorbentassay,ELISA)检测患者血清IL-6、IL-17水平并分析其与OSAHS的相关性。结果：与健康对照组比较，OSAHS组的血清II-6.TL-17水平均升高，差异有统计学意义(P〈0.05),且血清IL-6、IL-17水平随OSA
3、HS分布严重程度的升高而升高。OSAHS组的血清IL-6、IL-17水平与AI1I呈正相关("0.868,P<0.05；“0.896,P<0.05),而与LS&02呈负相关(r=-0.769,P<0.05；尸-0.703,P<0.05)o结论:血清炎性因子IL-6、IL-17水平在OSAHS组患者中升高，提示英参与OSAHS疾病进程，可以作为OSAHS严重程度的生物学指标。【关键词】阻塞性睡眠呼吸暂停低通气综合征；几-6；TL-17；酶联免疫吸附法[Abstract]Objective：Todiscussthechangean
4、dclinicalsignificanceofserumIL~6andIL-17levelsinpatientswithobstruetivesleepapnea-hypopneasyndromes(OSAHS)•Method：102patientswithOSAHSwhowerediagnosedbypolysomnagraphy(PSG)and98casesofhealthyascontrolgroupwereselectedfromMay2013toOctomber2014,thegeneralclinicaldata,
5、apnea-hypopneaindex(AHI)andlowestarterialoxygensaturation(LSaO2)ofthemwereretrospectivelyanalyzed.TheserumIL一6andTL-17levelsweredeterminedbyenzyme-linkedimmunosorbentassay(ELISA),anditscorrelationwithOSAHSwereanalyzed.Result：Comparedwiththecontrolgroup,theserumIL~6a
6、ndIL-17levelsofOSAHSpatientsincreasedandincreasedwiththeseverityofOSAHS,therewasstatisticallysignifleantdifferencebetweenthem(P<0.05)•TheserumIL~6andIL-17levelsofOSAHSpatientspresentedpositivelycorrelatedwithAHI(r=0.868,P<0.05；r=0.896,P<0.05),butnegativelycorrelated
7、withLSaO2(r二-0.769,P<0.05；r=-0.703,P<0.05)•Conclusion：ThelevelsofseruminflammatorycytokinesIL-6andTL-17arehigherinOSAHSgroup,suggestsitsparticipationinOSAHSdiseaseprocess,anditcanbeusedasbiologicalindexoftheseverityofOSAHS・[Keywords]Obstructivesieepapnea-hypopneasyn
8、dromes；TL-6；IL-17；Enzyme-1inkediinmunosorbentassayFirst-author?saddress:InnerMongoliaAutonomousRegionPeople'sHospital,Hohhot010017,Chinado
